9KXY: Human B0AT1-ACE2 complex with compound1

Structure of human B0AT1-ACE2 complex with compound1. Determined by electron microscopy at 2.82 Å resolution. Released 10 Dec 2025.

Method
Electron microscopy
Resolution
2.82 Å
Organism
Homo sapiens
Chains
4
Atoms
21,725
Mol. weight
337.61 kDa
Ligands
A1L6U
Released
10 Dec 2025

Explore 9KXY in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9KXY contains 165 α-helices and 37 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 39 helices, 2 β-strands

ElementResiduesLengthSheet
α-helix18-214
α-helix39-5315
α-helix57-648
α-helix71-777
α-helix78-825
α-helix83-9614
α-helix100-1078
α-helix113-14129
α-helix164-1685
α-helix171-1744
α-helix175-1806
α-helix195-21117
α-helix216-24328
α-helix247-2559
α-helix259-2635
α-helix265-27814
α-helix285-2906
α-helix299-34850
α-helix350-3512
α-helix361-37010
α-helix372-3754
α-helix376-3783
α-helix385-3895
α-helix3971
α-helix398-4036
α-helix404-4085
α-helix413-44533
α-helix457-46913
α-helix470-4745
α-helix478-49114
α-helix493-50614
α-helix511-52212
α-helix525-5273
α-helix528-5325
α-helix533-5375
α-helix538-55518
β-strand559-56021
β-strand576-57721
α-helix578-5792
α-helix582-5898
α-helix591-60515
Chain B: 43 helices, 16 β-strands
ElementResiduesLengthSheet
α-helix22-5231
α-helix56-8025
α-helix85-873
α-helix91-10111
α-helix104-1074
α-helix110-12920
β-strand131-13332
β-strand141-14332
α-helix144-1485
α-helix149-1535
α-helix158-16811
α-helix169-1735
α-helix174-19320
α-helix199-2046
β-strand20913
β-strand21713
α-helix219-25133
β-strand26014
β-strand262-26325
α-helix264-2663
α-helix276-2783
α-helix279-2824
α-helix294-2996
α-helix304-31714
α-helix321-3244
α-helix325-3295
β-strand347-35046
β-strand356-35946
α-helix366-38520
α-helix390-3923
α-helix400-41314
α-helix415-4217
α-helix432-46534
α-helix470-4723
α-helix473-4808
α-helix481-4855
β-strand487-48825
α-helix499-5024
α-helix504-5074
α-helix513-53321
α-helix539-5413
α-helix548-56013
α-helix566-5738
α-helix582-59817
β-strand60714
α-helix614-6163
α-helix6171
β-strand618-62257
α-helix624-6285
α-helix637-65822
α-helix667-6693
β-strand670-67347
β-strand681-68557
β-strand686-68728
β-strand690-69458
α-helix695-6962
α-helix697-71418
β-strand722-72437
α-helix741-76626
Chain C: 41 helices, 3 β-strands
ElementResiduesLengthSheet
α-helix11-144
β-strand1519
α-helix18-214
α-helix39-5315
α-helix57-648
α-helix71-777
α-helix78-825
α-helix83-9614
α-helix100-1078
α-helix113-14129
α-helix164-1685
α-helix171-1744
α-helix175-1806
α-helix195-21117
α-helix216-24328
α-helix250-2556
α-helix259-2624
α-helix265-27814
α-helix285-2906
α-helix299-34749
α-helix350-3512
α-helix357-3593
α-helix361-37010
α-helix373-3764
α-helix385-3906
α-helix392-3943
α-helix3971
α-helix398-4036
α-helix404-4085
α-helix413-44533
α-helix457-46913
α-helix470-4745
α-helix478-48811
α-helix492-50312
α-helix504-5085
α-helix511-52212
α-helix528-5325
α-helix533-5375
α-helix538-55518
β-strand559-562410
β-strand574-577410
α-helix578-5792
α-helix580-58910
α-helix592-60514
Chain D: 42 helices, 16 β-strands
ElementResiduesLengthSheet
α-helix22-5332
α-helix56-8227
α-helix91-10111
α-helix104-1074
α-helix110-12920
β-strand131-133311
β-strand141-143311
α-helix144-1485
α-helix149-1535
α-helix158-16811
α-helix169-1735
α-helix174-19320
α-helix199-2046
β-strand209112
β-strand217112
α-helix219-25133
β-strand260113
β-strand262-263214
α-helix264-2663
α-helix276-2783
α-helix279-2824
α-helix294-2996
α-helix304-31714
α-helix320-3245
α-helix325-3295
β-strand347-352615
β-strand355-359515
α-helix366-38419
α-helix385-3873
α-helix390-3923
α-helix400-41314
α-helix415-4206
α-helix432-44514
α-helix449-46517
α-helix470-4723
α-helix473-48311
β-strand487-488214
α-helix499-5024
α-helix504-5074
α-helix513-53321
α-helix539-5413
α-helix548-56013
α-helix566-5738
α-helix582-5876
α-helix589-59810
β-strand607113
β-strand618-622516
α-helix632-6343
α-helix637-65822
α-helix667-6693
β-strand670-673416
β-strand680-685616
β-strand686-687217
β-strand690-694517
α-helix695-6962
α-helix697-71418
β-strand722-724316
α-helix741-76626

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Sodium-dependent neutral amino acid transporter B(0)AT1A, Cprotein654Homo sapiensQ695T7 (AlphaFold model)
Angiotensin-converting enzyme 2B, Dprotein806Homo sapiensQ9BYF1 (AlphaFold model)
Sequence of entity 1 (A, C), FASTA
>9KXY_1 Sodium-dependent neutral amino acid transporter B(0)AT1 (chains A, C)
MADYKDDDDKSGPDEVDASGRVRLVLPNPGLDARIPSLAELETIEQEEASSRPKWDNKAQ
YMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGS
LGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQT
GYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTG
KAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFS
LAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTN
ILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAF
IVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTG
LICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEF
MIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPN
WVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPGDHQGLVSTLSTASMNGDLKY
Sequence of entity 2 (B, D), FASTA
>9KXY_2 Angiotensin-converting enzyme 2 (chains B, D)
MRSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENV
QNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTI
LNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPL
YEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEH
LHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVD
QAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRIL
MCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLK
SIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWE
MKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPL
HKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQN
KNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVK
NQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLND
NSLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGEN
PYASIDISKGENNPGFQNTDDVQTSF

Ligands and cofactors

IDNameFormulaCopies
A1L6U3-(3-bromophenyl)-~{N}-ethyl-propanamideC11 H14 Br N O2

Primary citation

Structure-guided development of a potent human B 0 AT1 inhibitor effective in a mouse model of phenylketonuria. Imazu, T., Akashi, T., Hiraizumi, M. et al. Commun Biol (2026). DOI 10.1038/s42003-026-10535-y · PubMed

Other PDB entries of the same protein (UniProt Q695T7 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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