P0AA04: Phosphocarrier protein HPr (ptsH)

Phosphocarrier protein HPr (ptsH) is a 85-residue protein from Escherichia coli (strain K12). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P0AA04.

Gene
ptsH
Organism
Escherichia coli (strain K12)
Length
85 residues
Mean pLDDT
96.6
Model
AF-P0AA04-F1 v6
Model created
1 Aug 2025
PDB structures
22

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Model confidence (pLDDT)

The mean pLDDT of this model is 96.6 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

pLDDT bandMeaningShare of residues
Above 90Very high: backbone and side chains are usually accurate97%
70 to 90Confident: backbone generally right4%
50 to 70Low: treat with caution0%
Below 50Very low: often disordered regions0%

What pLDDT means and how to read it

Function

General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain

Subcellular location

Cytoplasm

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

PDB IDMethodResolutionChains and residues
3CCDX-ray1.0 ÅA/B=1-85
1OPDX-ray1.5 ÅA=1-85
1CM3X-ray1.6 ÅA=1-85
1CM2X-ray1.8 ÅA=1-85
1POHX-ray2.0 ÅA=1-85
4XWJX-ray2.1 ÅB=1-85
2JELX-ray2.5 ÅP=1-85
5YA1X-ray2.7 ÅC/D=1-85
5YA2X-ray2.7 ÅC/D=1-85
5YA0X-ray3.0 ÅC/D=1-85
6KCRX-ray3.5 ÅB/D=1-85
1GGRNMRB=1-85
1HDNNMRA=1-85
1J6TNMRB=1-85
1PFHNMRA=1-85
1VRCNMRC/D=1-85
2LRKNMRD=1-85
2LRLNMRD=1-85
2XDFNMRC/D=1-85
3EZANMRB=1-85

Showing 20 of 22 experimental structures (best resolution first).

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