Receptor-type tyrosine-protein phosphatase F (PTPRF) is a 1907-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P10586.
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The mean pLDDT of this model is 82.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 32% |
| 70 to 90 | Confident: backbone generally right | 53% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity
Interacts with GRIP1 (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3. Interacts with INSR
Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4N5U | X-ray | 1.46 Å | A=601-705 |
| 6TPU | X-ray | 1.55 Å | A/B=513-706 |
| 6TPV | X-ray | 1.8 Å | A/B=319-512 |
| 1LAR | X-ray | 2.0 Å | A/B=1333-1907 |
| 2YD8 | X-ray | 2.05 Å | A=29-231 |
| 2YD5 | X-ray | 2.2 Å | A=29-231 |
| 6KR4 | X-ray | 2.85 Å | A/B/C/D=1332-1907 |
| 6TPW | X-ray | 2.9 Å | A=319-706 |
| 6TPT | X-ray | 3.2 Å | A=512-706 |
| 2DJU | NMR | A=319-411 | |
| 2DN7 | NMR | A=821-914 | |
| 2EDX | NMR | A=596-716 | |
| 2EDY | NMR | A=915-1010 |
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