Tyrosine-protein phosphatase non-receptor type 23 (PTPN23) is a 1636-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9H3S7.
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The mean pLDDT of this model is 69.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 41% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 37% |
What pLDDT means and how to read it
Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552). Plays a role in ciliogenesis (PubMed:20393563)
Interacts with GRAP2 and GRB2 (PubMed:21179510). Interacts with UBAP1 (PubMed:21757351, PubMed:27839950). Interacts with CHMP4B (PubMed:18434552)
Nucleus, Cytoplasm, Cytoplasmic vesicle, Endosome, Cytoplasm, cytoskeleton, cilium basal body, Early endosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5MK2 | X-ray | 1.7 Å | A/B=1-361 |
| 5MK0 | X-ray | 1.76 Å | A/C=1-361 |
| 5MJZ | X-ray | 1.87 Å | A/B=1-361 |
| 3RAU | X-ray | 1.95 Å | A/B=2-361 |
| 5CRV | X-ray | 2.0 Å | A/B=1-361 |
| 5MK3 | X-ray | 2.0 Å | A/B/C/D=1-361 |
| 5MJY | X-ray | 2.25 Å | A/B/C/D=1-361 |
| 5CRU | X-ray | 2.4 Å | A/B/C/D=1-361 |
| 5MK1 | X-ray | 2.5 Å | A/B/C/D=1-361 |
| 5LM2 | X-ray | 2.54 Å | A/B=362-713 |
| 5LM1 | X-ray | 2.55 Å | A=362-713 |
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