Crystal structure of the His Domain Protein Tyrosine Phosphatase (HD-PTP/PTPN23) Bro1 domain (CHMP4B peptide complex structure). Determined by X-ray diffraction at 1.7 Å resolution. Released 16 Aug 2017.
Explore 5MK2 in 3D Show helices and sheets RCSB PDB PDBe
5MK2 contains 39 α-helices and 6 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 4-8 | 5 | |
| α-helix | 13-16 | 4 | |
| β-strand | 17-20 | 4 | 1 |
| α-helix | 22-29 | 8 | |
| α-helix | 30-34 | 5 | |
| α-helix | 42-56 | 15 | |
| α-helix | 62-81 | 20 | |
| β-strand | 94-97 | 4 | 1 |
| β-strand | 104-107 | 4 | 1 |
| α-helix | 110-131 | 22 | |
| α-helix | 137-160 | 24 | |
| α-helix | 167-169 | 3 | |
| α-helix | 171-195 | 25 | |
| α-helix | 200-221 | 22 | |
| α-helix | 224-230 | 7 | |
| α-helix | 232-262 | 31 | |
| α-helix | 266-286 | 21 | |
| α-helix | 292-315 | 24 | |
| α-helix | 316-320 | 5 | |
| α-helix | 322-324 | 3 | |
| α-helix | 341-343 | 3 | |
| α-helix | 349-352 | 4 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 4-8 | 5 | |
| α-helix | 13-16 | 4 | |
| β-strand | 17-20 | 4 | 2 |
| α-helix | 23-29 | 7 | |
| α-helix | 30-34 | 5 | |
| α-helix | 42-56 | 15 | |
| α-helix | 62-79 | 18 | |
| β-strand | 94-97 | 4 | 2 |
| β-strand | 104-107 | 4 | 2 |
| α-helix | 110-131 | 22 | |
| α-helix | 137-160 | 24 | |
| α-helix | 167-169 | 3 | |
| α-helix | 171-195 | 25 | |
| α-helix | 200-221 | 22 | |
| α-helix | 224-230 | 7 | |
| α-helix | 232-262 | 31 | |
| α-helix | 266-286 | 21 | |
| α-helix | 292-315 | 24 | |
| α-helix | 316-320 | 5 | |
| α-helix | 327-329 | 3 | |
| α-helix | 331-335 | 5 | |
| α-helix | 349-352 | 4 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 213-221 | 9 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Tyrosine-protein phosphatase non-receptor type 23 | A, B | protein | 361 | Homo sapiens | Q9H3S7 (AlphaFold model) |
| Charged multivesicular body protein 4b | C | protein | 20 | Homo sapiens | Q9H444 (AlphaFold model) |
>5MK2_1 Tyrosine-protein phosphatase non-receptor type 23 (chains A, B) MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQNAVRVPR DFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHEDIKYEQACILYN LGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAYSVDMSRQILTLNVNL MLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKL VQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRF TMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKL V
>5MK2_2 Charged multivesicular body protein 4b (chains C) KKKEEEDDDMKELENWAGSM
Structural Basis for Specific Interaction of TGF beta Signaling Regulators SARA/Endofin with HD-PTP. Gahloth, D., Levy, C., Walker, L. et al. Structure (2017) 25:1011-1024.e4. DOI 10.1016/j.str.2017.05.005 · PubMed
Other PDB entries of the same protein (UniProt Q9H3S7 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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