3HOR: Actin-binding domain of human filamin A

Structure of the actin-binding domain of human filamin A (reduced). Determined by X-ray diffraction at 2.7 Å resolution. Released 13 Oct 2009.

Method: X-ray diffraction
Resolution: 2.7 Å
Organism: Homo sapiens
Chains: 2
Atoms: 3,375
Mol. weight: 61.39 kDa
Ligands: PO4
Released: 13 Oct 2009

Explore 3HOR in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3HOR contains 28 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 13 helices, 0 β-strands

Element	Residues	Length
α-helix	44-57	14
α-helix	58-60	3
α-helix	75-85	11
α-helix	100-116	17
α-helix	126-130	5
α-helix	134-144	11
α-helix	145-150	6
α-helix	168-179	12
α-helix	196-205	10
α-helix	213-215	3
α-helix	221-236	16
α-helix	244-247	4
α-helix	254-261	8

Chain B: 15 helices, 0 β-strands

Element	Residues	Length
α-helix	45-56	12
α-helix	62-64	3
α-helix	75-85	11
α-helix	100-116	17
α-helix	126-130	5
α-helix	134-145	12
α-helix	146-151	6
α-helix	173-179	7
α-helix	196-205	10
α-helix	213-215	3
α-helix	221-231	11
α-helix	232-236	5
α-helix	244-247	4
α-helix	254-261	8
α-helix	263-266	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Filamin-A	A, B	protein	272	Homo sapiens	P21333 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>3HOR_1 Filamin-A (chains A, B)
GAMASSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHL
KCVSKRIANLQTDLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRE
SIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTPKQRLLGWIQ
NKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLG
IPQVITPEEIVDPNVDEHSVMTYLSQFPKAKL

Ligands and cofactors

ID	Name	Formula	Copies
PO4	Phosphate ion	O4 P	4

Primary citation

Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders. Clark, A.R., Sawyer, G.M., Robertson, S.P. et al. Hum Mol Genet (2009) 18:4791-4800. DOI 10.1093/hmg/ddp442 · PubMed

Other PDB entries of the same protein (UniProt P21333 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3CNK 1.65 Å, Crystal Structure of the dimerization domain of human filamin A
4M9P 1.72 Å, Crystal structure of the human filamin A Ig-like domains 3-5
7SC4 1.85 Å, filamin complex-1
2W0P 1.9 Å, Crystal structure of the filamin A repeat 21 complexed with the migfilin peptide
4P3W 2.0 Å, Crystal structure of the human filamin A Ig-like domains 20-21 in complex with migfilin…
2BRQ 2.1 Å, Crystal structure of the filamin A repeat 21 complexed with the integrin beta7…
2JF1 2.2 Å, Crystal structure of the filamin a repeat 21 complexed with the integrin BETA2…
9LWX 2.29 Å, Crystal structure of the Filamin A repeat 21
3HOC 2.3 Å, Structure of the actin-binding domain of human filamin A mutant E254K
3HOP 2.3 Å, Structure of the actin-binding domain of human filamin A
6EW1 2.31 Å, Crystal structure of the Filamin A Ig-like domains 3-5 mutant P637Q
2BP3 2.32 Å, Crystal structure of Filamin A domain 17 and GPIb alpha cytoplasmic domain complex

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