5NP0: Closed dimer of human ATM

Closed dimer of human ATM (Ataxia telangiectasia mutated). Determined by electron microscopy at 5.7 Å resolution. Released 17 May 2017.

Method
Electron microscopy
Resolution
5.7 Å
Organism
Homo sapiens
Chains
2
Atoms
25,074
Mol. weight
704.79 kDa
Released
17 May 2017

Explore 5NP0 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5NP0 contains 366 α-helices and 18 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and B: 183 helices, 9 β-strands

ElementResiduesLengthSheet
α-helix6-1510
α-helix22-3413
α-helix42-443
α-helix60-645
α-helix65-695
α-helix70-778
α-helix94-11017
α-helix117-1248
α-helix146-1538
α-helix156-1616
α-helix168-1769
α-helix183-19715
α-helix205-2073
α-helix208-21912
α-helix224-2274
α-helix228-2303
α-helix231-2366
α-helix243-2486
α-helix249-2513
α-helix253-2553
α-helix267-2737
α-helix274-2785
α-helix279-2879
α-helix310-32213
α-helix339-3424
α-helix345-35511
α-helix413-4197
α-helix433-4397
α-helix440-4423
α-helix4441
α-helix445-4495
α-helix455-4573
α-helix460-4667
α-helix477-49115
α-helix499-5024
α-helix503-5086
α-helix509-5146
α-helix523-53210
α-helix540-5456
α-helix560-5667
α-helix579-5879
α-helix604-6085
α-helix609-6179
α-helix626-63712
α-helix652-6576
α-helix658-6625
α-helix686-69813
α-helix700-7067
α-helix712-72110
α-helix732-7365
α-helix737-7415
α-helix746-75813
α-helix827-8337
α-helix844-85916
α-helix877-8826
α-helix885-8895
α-helix922-93211
α-helix944-95815
α-helix970-98112
α-helix988-100215
α-helix1014-10207
α-helix1043-10519
α-helix1057-10615
α-helix1062-10676
α-helix1071-108919
α-helix1105-11106
α-helix1111-11166
α-helix1117-11259
α-helix1133-114210
α-helix1150-116011
α-helix1165-117612
α-helix1191-11955
α-helix1198-12014
α-helix1211-12177
α-helix1218-12214
α-helix1237-124610
α-helix1250-126920
α-helix1277-128610
α-helix1287-12904
α-helix1294-12985
α-helix1308-13114
α-helix1342-13465
α-helix1367-13726
α-helix1380-13878
α-helix1412-14198
α-helix1420-14223
α-helix1426-14305
α-helix1437-144711
α-helix1452-14543
α-helix1457-147216
α-helix1478-150023
α-helix1515-15217
α-helix1533-154412
α-helix1550-156213
α-helix1569-15757
α-helix1577-15859
α-helix1594-160310
α-helix1610-16189
α-helix1619-16213
α-helix1631-16377
α-helix1644-16496
α-helix1650-16523
α-helix1659-166810
α-helix1678-16825
α-helix1683-16853
α-helix1702-17076
α-helix1713-172513
α-helix1736-17438
α-helix1746-175510
α-helix1760-17689
α-helix1812-18154
α-helix1824-183512
α-helix1842-185312
α-helix1856-187318
α-helix1877-189216
α-helix1894-18963
α-helix1902-191413
α-helix1917-19193
α-helix1926-19338
α-helix1938-194811
α-helix1951-197525
α-helix1999-201214
α-helix2015-20184
α-helix2022-20254
α-helix2030-20389
α-helix2042-205110
α-helix2058-207215
α-helix2075-20839
α-helix2092-210514
α-helix2110-21134
α-helix2124-213613
α-helix2142-216019
α-helix2169-218517
α-helix2187-21904
α-helix2195-221117
α-helix2217-223620
α-helix2237-22393
α-helix2242-226524
α-helix2269-228012
α-helix2282-22843
α-helix2290-230112
α-helix2308-232316
α-helix2330-234819
α-helix2353-236917
α-helix2377-240226
α-helix2403-24075
α-helix2408-241912
α-helix2438-24414
α-helix2445-245915
α-helix2462-247615
α-helix2481-249414
α-helix2500-25078
α-helix2508-25103
α-helix2513-25164
α-helix2517-25193
α-helix2520-25234
α-helix2524-25263
α-helix2535-25395
α-helix2540-255011
α-helix2553-256513
α-helix2597-261216
α-helix2619-263214
α-helix2654-26607
α-helix2690-26912
β-strand269211
α-helix2693-26942
β-strand270011
β-strand2702-270542
β-strand2711-271442
β-strand271513
α-helix2722-274120
α-helix2743-27486
β-strand2757-276153
β-strand2764-276743
α-helix2776-27838
α-helix2794-28018
α-helix2802-28054
α-helix2814-282613
α-helix2831-28388
α-helix2842-286019
α-helix2862-28665
β-strand287914
β-strand288414
α-helix2911-29177
α-helix2923-29253
α-helix2927-295327
α-helix2966-29727
α-helix2975-29806
α-helix2999-301618
α-helix3029-304012
α-helix3042-30465
α-helix3050-30534

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Serine-protein kinase ATMA, Bprotein3066Homo sapiensQ13315
Sequence of entity 1 (A, B), FASTA
>5NP0_1 Serine-protein kinase ATM (chains A, B)
MDYKDDDDKHMSLVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSK
QGKYLNWDAVFRFLQKYIQKETECLRIAKPNVSASTQASRQKKMQEISSLVKYFIKCANR
RAPRLKCQELLNYIMDTVKDSSNGAIYGADCSNILLKDILSVRKYWCEISQQQWLELFSV
YFRLYLKPSQDVHRVLVARIIHAVTKGCCSQTDGLNSKFLDFFSKAIQCARQEKSSSGLN
HILAALTIFLKTLAVNFRIRVCELGDEILPTLLYIWTQHRLNDSLKEVIIELFQLQIYIH
HPKGAKTQEKGAYESTKWRSILYNLYDLLVNEISHIGSRGKYSSGFRNIAVKENLIELMA
DICHQVFNEDTRSLEISQSYTTTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQNDFDLV
PWLQIATQLISKYPASLPNCELSPLLMILSQLLPQQRHGERTPYVLRCLTEVALCQDKRS
NLESSQKSDLLKLWNKIWCITFRGISSEQIQAENFGLLGAIIQGSLVEVDREFWKLFTGS
ACRPSCPAVCCLTLALTTSIVPGTVKMGIEQNMCEVNRSFSLKESIMKWLLFYQLEGDLE
NSTEVPPILHSNFPHLVLEKILVSLTMKNCKAAMNFFQSVPECEHHQKDKEELSFSEVEE
LFLQTTFDKMDFLTIVRECGIEKHQSSIGFSVHQNLKESLDRCLLGLSEQLLNNYSSEIT
NSETLVRCSRLLVGVLGCYCYMGVIAEEEAYKSELFQKAKSLMQCAGESITLFKNKTNEE
FRIGSLRNMMQLCTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDIADICKSLASFIKKPF
DRGEVESMEDDTNGNLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTIGAINPLAEEYL
SKQDLLFLDMLKFLCLCVTTAQTNTVSFRAADIRRKLLMLIDSSTLEPTKSLHLHMYLML
LKELPGEEYPLPMEDVLELLKPLSNVCSLYRRDQDVCKTILNHVLHVVKNLGQSNMDSEN
TRDAQGQFLTVIGAFWHLTKERKYIFSVRMALVNCLKTLLEADPYSKWAILNVMGKDFPV
NEVFTQFLADNHHQVRMLAAESINRLFQDTKGDSSRLLKALPLKLQQTAFENAYLKAQEG
MREMSHSAENPETLDEIYNRKSVLLTLIAVVLSCSPICEKQALFALCKSVKENGLEPHLV
KKVLEKVSETFGYRRLEDFMASHLDYLVLEWLNLQDTEYNLSSFPFILLNYTNIEDFYRS
CYKVLIPHLVIRSHFDEVKSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDSGMAQ
QRETATKVYDMLKSENLLGKQIDHLFISNLPEIVVELLMTLHEPANSSASQSTDLCDFSG
DLDPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEILSKSPDSYQKILLAICEQAAETN
NVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQRPSCIMDVSLRS
FSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNK
DNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTR
LEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEA
VGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVR
SAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLD
DINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDIL
LQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPANLDSESEHFFRCCLDKKSQRTML
AVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQ
EKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPI
TRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKD
WCPELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYA
RVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQ
LLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQL
PERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSL
KLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSL
ARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDEL
ALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMK
IPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDE
FLTKPEVARRSRITKNVPKQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIIL
ANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEF
RLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKL
TICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQK
KSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGD
RHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRC
CEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQE
CKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFP
GWKAWV

Primary citation

Structures of closed and open conformations of dimeric human ATM. Baretic, D., Pollard, H.K., Fisher, D.I. et al. Sci Adv (2017) 3:e1700933-e1700933. DOI 10.1126/sciadv.1700933 · PubMed

Other PDB entries of the same protein (UniProt Q13315), best resolution first:

Browse structure collections

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