7NI5: Human ATM kinase with bound inhibitor KU-55933

Human ATM kinase with bound inhibitor KU-55933. Determined by electron microscopy at 2.78 Å resolution. Released 1 Sept 2021.

Method
Electron microscopy
Resolution
2.78 Å
Organism
Homo sapiens
Chains
2
Atoms
45,052
Mol. weight
710.11 kDa
Ligands
UF8, ZN
Released
1 Sept 2021

Explore 7NI5 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7NI5 contains 358 α-helices and 49 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 177 helices, 23 β-strands

ElementResiduesLengthSheet
α-helix4-1512
α-helix20-3516
α-helix37-4913
α-helix57-7620
α-helix85-10824
α-helix117-12913
α-helix135-14814
α-helix153-1586
α-helix161-17616
α-helix181-20121
α-helix204-2063
α-helix209-22214
α-helix229-24315
α-helix248-26821
α-helix273-29018
α-helix298-3003
α-helix306-32419
α-helix341-3422
α-helix343-35614
α-helix393-4019
α-helix410-42213
α-helix424-4263
α-helix429-4313
α-helix432-44211
α-helix452-46918
α-helix474-49219
α-helix495-4973
α-helix501-51313
α-helix521-5277
α-helix528-5303
α-helix536-54813
α-helix550-5534
α-helix571-58111
α-helix597-6004
α-helix603-6042
α-helix608-6158
α-helix620-6289
α-helix631-6333
α-helix646-65510
α-helix684-70320
α-helix712-73120
α-helix737-7426
α-helix744-76522
α-helix771-78616
α-helix795-80612
α-helix809-82315
α-helix892-91019
α-helix911-9133
α-helix920-93011
α-helix941-95313
α-helix960-9623
α-helix963-9708
α-helix973-9797
α-helix984-99411
α-helix995-9973
α-helix1008-103023
α-helix1036-105217
β-strand1060-106341
β-strand1066-106941
α-helix1070-10756
α-helix1076-10794
α-helix1083-10919
α-helix1093-10964
β-strand109812
α-helix11091
β-strand111012
α-helix1111-11122
α-helix1113-113523
α-helix1140-116425
α-helix1169-117810
α-helix1179-11835
α-helix1187-120115
α-helix1206-12127
α-helix1214-122310
α-helix1227-12293
α-helix1237-12393
α-helix1244-126017
α-helix1265-127410
α-helix1279-12857
α-helix1287-12926
α-helix1295-12995
α-helix1306-132318
α-helix1332-13376
α-helix1340-13489
β-strand135113
α-helix1373-13753
β-strand138113
α-helix1383-139513
α-helix1405-14106
α-helix1414-142815
α-helix1433-145119
α-helix1456-14583
α-helix1461-147717
α-helix1485-150925
α-helix1517-15248
α-helix1525-15295
α-helix1532-154211
α-helix1543-15475
α-helix1556-15605
α-helix1563-15664
α-helix1572-158211
α-helix1590-160011
α-helix1607-16104
α-helix1611-162111
α-helix1625-163410
α-helix1639-16413
α-helix1643-165715
α-helix1664-167512
β-strand168714
α-helix1695-17028
α-helix1708-172114
α-helix1728-174013
α-helix1744-175310
α-helix1759-17635
α-helix1780-17823
α-helix1792-17954
α-helix1802-181312
α-helix1828-18336
α-helix1836-185116
α-helix1857-187216
α-helix1903-191715
α-helix1920-19212
α-helix1927-19315
α-helix1938-194710
α-helix1951-196919
α-helix1987-199610
α-helix2001-201212
α-helix2016-20194
α-helix2029-203810
α-helix2042-205110
α-helix2057-207014
α-helix2074-208411
α-helix2093-210513
α-helix2124-213613
α-helix2140-215920
β-strand216514
α-helix2166-21683
α-helix2170-219021
α-helix2195-221117
α-helix2217-223620
α-helix2241-226424
α-helix2269-228113
α-helix2290-230112
α-helix2305-232218
α-helix2331-234818
α-helix2353-23553
α-helix2356-23616
α-helix2362-23676
α-helix2377-240529
α-helix2408-241811
α-helix2443-247432
α-helix2481-24833
α-helix2484-249310
α-helix2500-25067
α-helix2508-25103
α-helix2513-25197
α-helix2520-25245
α-helix2537-255115
α-helix2553-256412
α-helix2569-25735
α-helix2593-261220
α-helix2614-263219
α-helix2636-26383
β-strand2645-264625
α-helix2647-26482
α-helix2652-26554
β-strand266316
α-helix2670-26723
β-strand268216
β-strand2683-268647
β-strand2689-269025
β-strand2691-269227
β-strand2700-270677
β-strand2711-271887
α-helix2723-274119
α-helix2743-27486
β-strand2757-275937
β-strand2764-276857
β-strand2773-277538
α-helix2776-27805
α-helix2787-27904
α-helix2798-28069
α-helix2813-282513
α-helix2831-28333
α-helix2834-28385
α-helix2842-286524
α-helix2873-28753
β-strand2876-287948
β-strand2885-288738
α-helix2912-29165
α-helix2922-29243
α-helix2926-294015
α-helix2942-295312
α-helix2964-29707
α-helix3001-301818
β-strand3020-302129
β-strand3024-302529
α-helix3028-303912
α-helix3042-30454
α-helix3050-30523
Chain B: 181 helices, 26 β-strands
ElementResiduesLengthSheet
α-helix4-1512
α-helix20-3415
α-helix37-4913
α-helix57-7519
α-helix85-10824
α-helix117-12913
α-helix135-14410
α-helix145-1495
α-helix153-1586
α-helix161-17616
α-helix181-20121
α-helix204-2063
α-helix209-22214
α-helix229-24315
α-helix248-26821
α-helix273-29018
α-helix298-3003
α-helix306-32318
α-helix341-3422
α-helix343-35614
α-helix393-4019
α-helix406-42217
α-helix424-4263
α-helix429-4313
α-helix432-44211
α-helix452-46918
α-helix474-49219
α-helix495-4973
α-helix501-51313
α-helix521-5277
α-helix528-5303
α-helix536-54813
α-helix551-5533
α-helix571-58111
α-helix597-6004
α-helix603-6042
α-helix608-6158
α-helix620-6289
α-helix631-6333
α-helix646-65510
α-helix684-70320
α-helix712-73221
α-helix737-7426
α-helix744-76522
α-helix773-78614
α-helix795-80612
α-helix809-82315
α-helix887-8893
α-helix892-91019
α-helix911-9133
α-helix920-93011
α-helix941-95313
α-helix960-9623
α-helix963-9708
α-helix973-9797
α-helix984-99411
α-helix995-9973
α-helix1008-103023
α-helix1036-105217
β-strand1060-1063410
β-strand1066-1069410
α-helix1070-10756
α-helix1076-10794
α-helix1083-10908
α-helix1093-10964
β-strand1098111
α-helix11091
β-strand1110111
α-helix1111-11122
α-helix1113-113523
α-helix1144-116421
α-helix1169-118113
α-helix1187-120014
α-helix1206-12127
α-helix1214-122310
α-helix1227-12293
α-helix1237-12393
α-helix1244-126017
α-helix1265-127410
α-helix1279-12857
α-helix1287-12926
α-helix1295-12995
α-helix1307-132317
α-helix1332-13387
α-helix1340-13489
β-strand1351112
α-helix1374-13752
β-strand1381112
α-helix1383-139513
α-helix1405-14106
α-helix1413-142715
α-helix1432-145019
α-helix1456-14594
α-helix1461-147717
α-helix1485-150925
α-helix1517-15248
α-helix1525-15295
α-helix1532-154615
α-helix1553-15608
α-helix1563-15664
α-helix1569-15713
α-helix1572-158211
α-helix1590-160213
α-helix1607-16104
α-helix1611-162111
α-helix1625-163410
α-helix1639-16413
α-helix1643-165715
α-helix1667-16759
β-strand1687113
α-helix1695-17028
α-helix1708-172013
α-helix1721-17233
α-helix1729-174113
β-strand1743114
α-helix1744-175310
α-helix1759-17635
β-strand1775114
α-helix1792-17954
α-helix1803-181311
α-helix1828-18336
α-helix1836-185116
α-helix1857-187216
α-helix1903-191715
α-helix1920-19212
α-helix1927-19315
α-helix1938-194710
α-helix1951-197121
α-helix1987-199610
α-helix2001-201212
α-helix2016-20194
α-helix2024-20274
α-helix2029-203810
α-helix2042-205110
α-helix2057-207014
α-helix2074-208411
α-helix2091-20922
α-helix2093-210513
α-helix2124-213613
α-helix2140-215920
β-strand2165113
α-helix2166-21683
α-helix2170-219021
α-helix2195-221117
α-helix2217-223620
α-helix2241-226424
α-helix2269-228113
α-helix2290-230112
α-helix2305-232218
α-helix2328-234821
α-helix2353-23553
α-helix2356-23616
α-helix2362-23676
α-helix2377-240630
α-helix2408-241811
α-helix2443-247432
α-helix2481-24833
α-helix2484-249310
α-helix2498-25069
α-helix2508-25103
α-helix2513-25197
α-helix2520-25256
α-helix2537-255115
α-helix2553-256412
α-helix2569-25735
α-helix2593-261220
α-helix2614-263219
α-helix2636-26383
β-strand2645-2646215
α-helix2647-26482
α-helix2652-26554
β-strand2663116
α-helix2669-26724
β-strand2682116
β-strand2683-2686417
β-strand2689-2690215
β-strand2691-2692217
β-strand2700-2706717
β-strand2711-2718817
α-helix2723-274119
α-helix2743-27475
β-strand2753118
β-strand2757-2759317
β-strand2764-2768517
β-strand2773-2775318
α-helix2776-27805
α-helix2787-27904
α-helix2798-280710
α-helix2813-282513
α-helix2831-28333
α-helix2834-28385
α-helix2842-286524
α-helix2873-28753
β-strand2876-2879418
β-strand2885-2887318
α-helix2896-28983
α-helix2912-29165
α-helix2922-29243
α-helix2926-294015
α-helix2942-295312
α-helix2964-29707
α-helix3001-301818
β-strand3020-3021219
β-strand3024-3025219
α-helix3028-303912
α-helix3042-30454
α-helix3050-30523

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Serine-protein kinase ATMA, Bprotein3086Homo sapiensQ13315
Sequence of entity 1 (A, B), FASTA
>7NI5_1 Serine-protein kinase ATM (chains A, B)
MDYKDDDDKGTDYKDDDDKSGSLEVLFQGPMSLVLNDLLICCRQLEHDRATERKKEVEKF
KRLIRDPETIKHLDRHSDSKQGKYLNWDAVFRFLQKYIQKETECLRIAKPNVSASTQASR
QKKMQEISSLVKYFIKCANRRAPRLKCQELLNYIMDTVKDSSNGAIYGADCSNILLKDIL
SVRKYWCEISQQQWLELFSVYFRLYLKPSQDVHRVLVARIIHAVTKGCCSQTDGLNSKFL
DFFSKAIQCARQEKSSSGLNHILAALTIFLKTLAVNFRIRVCELGDEILPTLLYIWTQHR
LNDSLKEVIIELFQLQIYIHHPKGAKTQEKGAYESTKWRSILYNLYDLLVNEISHIGSRG
KYSSGFRNIAVKENLIELMADICHQVFNEDTRSLEISQSYTTTQRESSDYSVPCKRKKIE
LGWEVIKDHLQKSQNDFDLVPWLQIATQLISKYPASLPNCELSPLLMILSQLLPQQRHGE
RTPYVLRCLTEVALCQDKRSNLESSQKSDLLKLWNKIWCITFRGISSEQIQAENFGLLGA
IIQGSLVEVDREFWKLFTGSACRPSCPAVCCLTLALTTSIVPGTVKMGIEQNMCEVNRSF
SLKESIMKWLLFYQLEGDLENSTEVPPILHSNFPHLVLEKILVSLTMKNCKAAMNFFQSV
PECEHHQKDKEELSFSEVEELFLQTTFDKMDFLTIVRECGIEKHQSSIGFSVHQNLKESL
DRCLLGLSEQLLNNYSSEITNSETLVRCSRLLVGVLGCYCYMGVIAEEEAYKSELFQKAK
SLMQCAGESITLFKNKTNEEFRIGSLRNMMQLCTRCLSNCTKKSPNKIASGFFLRLLTSK
LMNDIADICKSLASFIKKPFDRGEVESMEDDTNGNLMEVEDQSSMNLFNDYPDSSVSDAN
EPGESQSTIGAINPLAEEYLSKQDLLFLDMLKFLCLCVTTAQTNTVSFRAADIRRKLLML
IDSSTLEPTKSLHLHMYLMLLKELPGEEYPLPMEDVLELLKPLSNVCSLYRRDQDVCKTI
LNHVLHVVKNLGQSNMDSENTRDAQGQFLTVIGAFWHLTKERKYIFSVRMALVNCLKTLL
EADPYSKWAILNVMGKDFPVNEVFTQFLADNHHQVRMLAAESINRLFQDTKGDSSRLLKA
LPLKLQQTAFENAYLKAQEGMREMSHSAENPETLDEIYNRKSVLLTLIAVVLSCSPICEK
QALFALCKSVKENGLEPHLVKKVLEKVSETFGYRRLEDFMASHLDYLVLEWLNLQDTEYN
LSSFPFILLNYTNIEDFYRSCYKVLIPHLVIRSHFDEVKSIANQIQEDWKSLLTDCFPKI
LVNILPYFAYEGTRDSGMAQQRETATKVYDMLKSENLLGKQIDHLFISNLPEIVVELLMT
LHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEILSK
SPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDVIY
TLIHYINQRPSCIMDVSLRSFSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLVYE
QVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPFSL
LEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLVVN
LLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKELQW
TFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFRTS
RKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLKPM
CEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPANLD
SESEHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSCAA
HFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEIYR
SIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQALQN
LGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESLYN
ALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGELFS
RSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIKDI
LTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLALS
ILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVAGN
YDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLREH
KIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLCSL
WLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRISM
DHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVPKQSSQLDEDRTEAANRIICTIR
SRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTMEIK
VDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQ
VFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKR
YRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRL
AYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRL
TRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYL
QQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSVGG
QVNLLIQQAIDPKNLSRLFPGWKAWV

Ligands and cofactors

IDNameFormulaCopies
UF82-morpholin-4-yl-6-thianthren-1-yl-pyran-4-oneC21 H17 N O3 S22
ZNZinc ionZn4

Primary citation

Molecular basis of human ATM kinase inhibition. Stakyte, K., Rotheneder, M., Lammens, K. et al. Nat Struct Mol Biol (2021) 28:789-798. DOI 10.1038/s41594-021-00654-x · PubMed

Other PDB entries of the same protein (UniProt Q13315), best resolution first:

Browse structure collections

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