7NI6: Human ATM kinase with bound ATPyS

Human ATM kinase with bound ATPyS. Determined by electron microscopy at 2.8 Å resolution. Released 1 Sept 2021.

Method
Electron microscopy
Resolution
2.8 Å
Organism
Homo sapiens
Chains
2
Atoms
23,079
Mol. weight
710.28 kDa
Ligands
ZN, AGS, MG
Released
1 Sept 2021

Explore 7NI6 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7NI6 contains 178 α-helices and 33 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 89 helices, 16 β-strands

ElementResiduesLengthSheet
α-helix1517-15248
α-helix1525-15295
α-helix1532-154211
α-helix1543-15475
α-helix1556-15605
α-helix1563-15664
α-helix1572-158211
α-helix1590-160112
α-helix1607-16104
α-helix1611-162313
α-helix1626-16349
α-helix1639-16413
α-helix1643-165715
α-helix1664-167815
β-strand168711
α-helix1694-17029
α-helix1706-172217
α-helix1727-174216
α-helix1744-175310
α-helix1759-17635
α-helix1788-17903
α-helix1792-17954
α-helix1802-181514
α-helix1822-18254
α-helix1828-18336
α-helix1835-185117
α-helix1857-187317
α-helix1903-191715
α-helix1920-19212
α-helix1927-19315
α-helix1938-194710
α-helix1951-197121
α-helix1987-199610
α-helix2001-201212
α-helix2016-20183
α-helix2029-203810
α-helix2042-205110
α-helix2057-207014
α-helix2074-208411
α-helix2093-210614
α-helix2124-213613
α-helix2140-216021
β-strand216511
α-helix2166-21683
α-helix2170-219021
α-helix2195-221117
α-helix2217-223620
α-helix2241-226424
α-helix2269-228113
α-helix2290-230112
α-helix2305-232218
α-helix2328-234821
α-helix2353-23564
α-helix2357-23615
α-helix2362-23676
α-helix2377-240630
α-helix2408-241811
α-helix2443-247634
α-helix2481-24833
α-helix2484-249310
α-helix2498-25069
α-helix2508-25103
α-helix2513-25197
α-helix2520-25256
α-helix2537-255115
α-helix2553-256412
α-helix2568-25736
α-helix2593-261220
α-helix2614-263219
α-helix2636-26383
β-strand2645-264622
α-helix2647-26482
α-helix2652-26554
β-strand2659-266353
β-strand2682-268653
β-strand2689-269022
β-strand2691-269223
β-strand2700-270673
β-strand2711-271883
α-helix2723-274119
α-helix2743-27475
β-strand2757-275933
β-strand2764-276853
α-helix2769-27702
β-strand2773-277534
α-helix2776-27805
α-helix2787-27904
α-helix2798-280710
α-helix2813-282513
α-helix2833-28386
α-helix2842-286524
α-helix2873-28753
β-strand2876-287944
β-strand2885-288734
α-helix2896-28983
α-helix2912-29165
α-helix2926-294015
α-helix2942-295312
α-helix2964-29707
α-helix3001-301818
β-strand3020-302125
β-strand3024-302525
α-helix3028-303912
α-helix3042-30465
α-helix3050-30523
Chain B: 89 helices, 17 β-strands
ElementResiduesLengthSheet
α-helix1517-15248
α-helix1525-15295
α-helix1532-154615
α-helix1553-15608
α-helix1563-15664
α-helix1572-158211
α-helix1590-160213
α-helix1607-16104
α-helix1611-162313
α-helix1626-16349
α-helix1639-16413
α-helix1643-165715
α-helix1664-167815
β-strand168716
α-helix1694-17029
α-helix1706-172116
α-helix1727-174115
α-helix1744-175310
α-helix1759-17646
α-helix1792-17954
α-helix1802-181514
α-helix1822-18254
α-helix1828-18336
α-helix1835-185117
α-helix1857-187216
α-helix1903-191816
α-helix1920-19212
α-helix1927-19315
α-helix1938-194710
α-helix1951-197121
α-helix1987-199711
α-helix2001-201212
α-helix2016-20194
α-helix2024-20274
α-helix2029-203810
α-helix2042-205110
α-helix2057-207014
α-helix2074-208512
α-helix2093-210513
α-helix2124-213613
α-helix2140-215920
β-strand216516
α-helix2166-21683
α-helix2170-219021
α-helix2195-221117
α-helix2217-223620
α-helix2241-226424
α-helix2269-228113
α-helix2290-230112
α-helix2305-232117
α-helix2328-234821
α-helix2353-23553
α-helix2356-23616
α-helix2362-23676
α-helix2377-240630
α-helix2408-241811
α-helix2443-247634
α-helix2481-24833
α-helix2484-249310
α-helix2498-25069
α-helix2508-25103
α-helix2513-25164
α-helix2520-25256
α-helix2537-255115
α-helix2553-256412
α-helix2568-25725
α-helix2593-261220
α-helix2614-263219
β-strand2645-264627
α-helix2647-26482
α-helix2652-26554
β-strand266318
β-strand268218
β-strand2683-268649
β-strand2689-269027
β-strand2691-269229
β-strand2700-270679
β-strand2711-271889
α-helix2723-274119
α-helix2743-27486
β-strand2757-275939
β-strand2764-276859
α-helix2769-27702
β-strand2773-2775310
α-helix2776-27805
α-helix2787-27904
α-helix2798-280710
α-helix2808-28103
α-helix2813-282513
α-helix2831-28333
α-helix2834-28385
α-helix2842-286524
α-helix2873-28753
β-strand2876-2879410
β-strand2885-2887310
α-helix2896-28983
α-helix2912-29187
α-helix2926-294015
α-helix2942-295312
α-helix2964-29707
α-helix3001-301818
β-strand3020-3021211
β-strand3024-3025211
α-helix3028-303912
α-helix3042-30476
α-helix3050-30523

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Serine-protein kinase ATMA, Bprotein3086Homo sapiensQ13315
Sequence of entity 1 (A, B), FASTA
>7NI6_1 Serine-protein kinase ATM (chains A, B)
MDYKDDDDKGTDYKDDDDKSGSLEVLFQGPMSLVLNDLLICCRQLEHDRATERKKEVEKF
KRLIRDPETIKHLDRHSDSKQGKYLNWDAVFRFLQKYIQKETECLRIAKPNVSASTQASR
QKKMQEISSLVKYFIKCANRRAPRLKCQELLNYIMDTVKDSSNGAIYGADCSNILLKDIL
SVRKYWCEISQQQWLELFSVYFRLYLKPSQDVHRVLVARIIHAVTKGCCSQTDGLNSKFL
DFFSKAIQCARQEKSSSGLNHILAALTIFLKTLAVNFRIRVCELGDEILPTLLYIWTQHR
LNDSLKEVIIELFQLQIYIHHPKGAKTQEKGAYESTKWRSILYNLYDLLVNEISHIGSRG
KYSSGFRNIAVKENLIELMADICHQVFNEDTRSLEISQSYTTTQRESSDYSVPCKRKKIE
LGWEVIKDHLQKSQNDFDLVPWLQIATQLISKYPASLPNCELSPLLMILSQLLPQQRHGE
RTPYVLRCLTEVALCQDKRSNLESSQKSDLLKLWNKIWCITFRGISSEQIQAENFGLLGA
IIQGSLVEVDREFWKLFTGSACRPSCPAVCCLTLALTTSIVPGTVKMGIEQNMCEVNRSF
SLKESIMKWLLFYQLEGDLENSTEVPPILHSNFPHLVLEKILVSLTMKNCKAAMNFFQSV
PECEHHQKDKEELSFSEVEELFLQTTFDKMDFLTIVRECGIEKHQSSIGFSVHQNLKESL
DRCLLGLSEQLLNNYSSEITNSETLVRCSRLLVGVLGCYCYMGVIAEEEAYKSELFQKAK
SLMQCAGESITLFKNKTNEEFRIGSLRNMMQLCTRCLSNCTKKSPNKIASGFFLRLLTSK
LMNDIADICKSLASFIKKPFDRGEVESMEDDTNGNLMEVEDQSSMNLFNDYPDSSVSDAN
EPGESQSTIGAINPLAEEYLSKQDLLFLDMLKFLCLCVTTAQTNTVSFRAADIRRKLLML
IDSSTLEPTKSLHLHMYLMLLKELPGEEYPLPMEDVLELLKPLSNVCSLYRRDQDVCKTI
LNHVLHVVKNLGQSNMDSENTRDAQGQFLTVIGAFWHLTKERKYIFSVRMALVNCLKTLL
EADPYSKWAILNVMGKDFPVNEVFTQFLADNHHQVRMLAAESINRLFQDTKGDSSRLLKA
LPLKLQQTAFENAYLKAQEGMREMSHSAENPETLDEIYNRKSVLLTLIAVVLSCSPICEK
QALFALCKSVKENGLEPHLVKKVLEKVSETFGYRRLEDFMASHLDYLVLEWLNLQDTEYN
LSSFPFILLNYTNIEDFYRSCYKVLIPHLVIRSHFDEVKSIANQIQEDWKSLLTDCFPKI
LVNILPYFAYEGTRDSGMAQQRETATKVYDMLKSENLLGKQIDHLFISNLPEIVVELLMT
LHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEILSK
SPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDVIY
TLIHYINQRPSCIMDVSLRSFSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLVYE
QVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPFSL
LEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLVVN
LLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKELQW
TFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFRTS
RKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLKPM
CEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPANLD
SESEHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSCAA
HFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEIYR
SIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQALQN
LGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESLYN
ALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGELFS
RSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIKDI
LTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLALS
ILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVAGN
YDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLREH
KIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLCSL
WLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRISM
DHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVPKQSSQLDEDRTEAANRIICTIR
SRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTMEIK
VDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQ
VFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKR
YRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRL
AYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRL
TRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYL
QQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSVGG
QVNLLIQQAIDPKNLSRLFPGWKAWV

Ligands and cofactors

IDNameFormulaCopies
ZNZinc ionZn2
AGSPhosphothiophosphoric acid-adenylate esterC10 H16 N5 O12 P3 S2
MGMagnesium ionMg2

Primary citation

Molecular basis of human ATM kinase inhibition. Stakyte, K., Rotheneder, M., Lammens, K. et al. Nat Struct Mol Biol (2021) 28:789-798. DOI 10.1038/s41594-021-00654-x · PubMed

Other PDB entries of the same protein (UniProt Q13315), best resolution first:

Browse structure collections

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