7SIC: Human ATM Dimer

Human ATM Dimer. Determined by electron microscopy at 2.51 Å resolution. Released 2 Feb 2022.

Method
Electron microscopy
Resolution
2.51 Å
Organism
Homo sapiens
Chains
2
Atoms
44,484
Mol. weight
703.32 kDa
Ligands
MG, ANP
Released
2 Feb 2022

Explore 7SIC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7SIC contains 348 α-helices and 50 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and B: 174 helices, 25 β-strands

ElementResiduesLengthSheet
α-helix6-1712
α-helix20-3314
α-helix36-416
α-helix57-7317
α-helix89-10820
α-helix117-12913
α-helix135-14410
α-helix145-1495
α-helix153-1586
α-helix161-17616
α-helix183-20119
α-helix207-2093
α-helix210-22213
α-helix229-24214
α-helix248-26821
α-helix273-29018
α-helix292-2943
α-helix298-3003
α-helix306-32318
α-helix340-3423
α-helix343-35614
α-helix393-40210
α-helix410-42213
α-helix424-4263
α-helix432-44211
α-helix452-46615
α-helix474-49219
α-helix501-51313
α-helix518-5203
α-helix521-5244
α-helix536-54813
α-helix572-5809
α-helix597-6004
α-helix608-6158
β-strand61711
α-helix620-6289
α-helix631-6322
α-helix646-65510
β-strand68211
α-helix684-70421
α-helix713-73119
α-helix737-7415
α-helix744-76522
α-helix771-78616
α-helix795-80612
α-helix809-82214
α-helix881-8833
α-helix887-8893
α-helix892-91120
α-helix920-93011
α-helix941-95313
α-helix960-9623
α-helix963-9708
α-helix973-9797
α-helix984-99411
α-helix995-9973
α-helix998-10025
α-helix1009-103022
α-helix1036-105217
β-strand1060-106342
β-strand1066-106942
α-helix1070-10767
α-helix1077-10793
α-helix1083-109210
α-helix1093-10964
β-strand109813
β-strand111013
α-helix1113-113220
α-helix1144-116421
α-helix1169-118113
α-helix1187-120115
α-helix1206-12127
α-helix1214-122310
α-helix1236-12383
α-helix1244-126118
α-helix1265-127511
α-helix1279-12857
α-helix1287-12948
α-helix1295-12973
α-helix1306-132217
α-helix1328-13303
α-helix1332-13387
α-helix1340-13489
β-strand135114
β-strand138114
α-helix1383-139614
α-helix1404-14085
α-helix1413-142816
α-helix1432-145019
α-helix1461-147717
α-helix1485-150824
α-helix1512-15143
α-helix1517-15248
α-helix1525-15284
α-helix1532-154211
α-helix1543-15475
α-helix1553-15608
α-helix1563-15664
α-helix1572-158211
α-helix1587-15893
α-helix1590-160112
α-helix1607-16104
α-helix1611-162313
α-helix1625-163410
α-helix1639-16413
α-helix1643-165816
α-helix1664-167714
β-strand168715
α-helix1694-17029
α-helix1706-172116
α-helix1727-174216
α-helix1744-175310
α-helix1759-17635
α-helix1792-17954
α-helix1802-181514
α-helix1822-18254
α-helix1828-18314
α-helix1835-185117
α-helix1857-187519
α-helix1903-191715
α-helix1920-19212
α-helix1927-19304
α-helix1938-194710
α-helix1951-197323
α-helix1986-199611
α-helix2001-201212
α-helix2016-20194
α-helix2029-203810
α-helix2042-205110
α-helix2057-207014
α-helix2074-208714
α-helix2093-210513
α-helix2124-213613
α-helix2140-215920
β-strand216515
α-helix2166-21683
α-helix2170-219021
α-helix2195-221117
α-helix2217-223620
α-helix2244-226421
α-helix2269-228113
α-helix2290-230112
α-helix2305-232218
α-helix2328-234821
α-helix2353-23564
α-helix2357-23615
α-helix2362-23709
α-helix2377-240529
α-helix2408-242114
α-helix2437-247539
α-helix2481-24833
α-helix2484-24929
α-helix2498-25069
α-helix2508-25103
α-helix2513-25197
α-helix2520-25245
α-helix2537-255115
α-helix2553-256412
α-helix2568-25725
α-helix2593-261220
α-helix2614-263219
α-helix2637-26404
β-strand2645-264626
α-helix2647-26482
α-helix2652-26554
β-strand266317
α-helix2668-26714
β-strand268217
β-strand2683-268648
β-strand2689-269026
β-strand2691-269228
α-helix2693-26942
β-strand2700-270678
β-strand2711-271888
α-helix2723-274018
α-helix2743-27475
β-strand2757-275938
β-strand2764-276858
β-strand2773-277539
α-helix2776-27816
α-helix2787-27915
α-helix2798-280710
α-helix2813-282513
α-helix2833-28386
α-helix2842-286625
α-helix2873-28753
β-strand2876-287949
β-strand2885-288739
α-helix2896-28994
α-helix2912-29165
α-helix2926-294015
α-helix2942-295312
α-helix2964-29707
α-helix3002-301817
β-strand3020110
β-strand3025110
α-helix3028-304013
α-helix3042-30465
α-helix3050-30523

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Serine-protein kinase ATMA, Bprotein3056Homo sapiensQ13315
Sequence of entity 1 (A, B), FASTA
>7SIC_1 Serine-protein kinase ATM (chains A, B)
MSLVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSKQGKYLNWDAV
FRFLQKYIQKETECLRIAKPNVSASTQASRQKKMQEISSLVKYFIKCANRRAPRLKCQEL
LNYIMDTVKDSSNGAIYGADCSNILLKDILSVRKYWCEISQQQWLELFSVYFRLYLKPSQ
DVHRVLVARIIHAVTKGCCSQTDGLNSKFLDFFSKAIQCARQEKSSSGLNHILAALTIFL
KTLAVNFRIRVCELGDEILPTLLYIWTQHRLNDSLKEVIIELFQLQIYIHHPKGAKTQEK
GAYESTKWRSILYNLYDLLVNEISHIGSRGKYSSGFRNIAVKENLIELMADICHQVFNED
TRSLEISQSYTTTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQNDFDLVPWLQIATQLI
SKYPASLPNCELSPLLMILSQLLPQQRHGERTPYVLRCLTEVALCQDKRSNLESSQKSDL
LKLWNKIWCITFRGISSEQIQAENFGLLGAIIQGSLVEVDREFWKLFTGSACRPSCPAVC
CLTLALTTSIVPGTVKMGIEQNMCEVNRSFSLKESIMKWLLFYQLEGDLENSTEVPPILH
SNFPHLVLEKILVSLTMKNCKAAMNFFQSVPECEHHQKDKEELSFSEVEELFLQTTFDKM
DFLTIVRECGIEKHQSSIGFSVHQNLKESLDRCLLGLSEQLLNNYSSEITNSETLVRCSR
LLVGVLGCYCYMGVIAEEEAYKSELFQKAKSLMQCAGESITLFKNKTNEEFRIGSLRNMM
QLCTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDIADICKSLASFIKKPFDRGEVESMED
DTNGNLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTIGAINPLAEEYLSKQDLLFLDM
LKFLCLCVTTAQTNTVSFRAADIRRKLLMLIDSSTLEPTKSLHLHMYLMLLKELPGEEYP
LPMEDVLELLKPLSNVCSLYRRDQDVCKTILNHVLHVVKNLGQSNMDSENTRDAQGQFLT
VIGAFWHLTKERKYIFSVRMALVNCLKTLLEADPYSKWAILNVMGKDFPVNEVFTQFLAD
NHHQVRMLAAESINRLFQDTKGDSSRLLKALPLKLQQTAFENAYLKAQEGMREMSHSAEN
PETLDEIYNRKSVLLTLIAVVLSCSPICEKQALFALCKSVKENGLEPHLVKKVLEKVSET
FGYRRLEDFMASHLDYLVLEWLNLQDTEYNLSSFPFILLNYTNIEDFYRSCYKVLIPHLV
IRSHFDEVKSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDSGMAQQRETATKVYD
MLKSENLLGKQIDHLFISNLPEIVVELLMTLHEPANSSASQSTDLCDFSGDLDPAPNPPH
FPSHVIKATFAYISNCHKTKLKSILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILK
IYHLFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQ
VCQTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDNENLYITIK
LLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQ
LELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVGSCLGEVGP
IDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNI
LATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDINLWIPLSE
NHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRN
LLSTHVQGFFTSCLRHFSQTSRSTTPANLDSESEHFFRCCLDKKSQRTMLAVVDYMRRQK
RPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKRSLAFEEG
SQSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEA
MWGKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHY
QAAWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCK
RSLESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQ
EPIMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQ
YNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRV
CGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDTQYQR
IENYMKSSEFENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRK
RFLCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLM
YQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVARR
SRITKNVPKQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKT
QRKGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPK
IIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPL
SQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVF
MDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINE
QSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRN
SQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQ
SFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV

Ligands and cofactors

IDNameFormulaCopies
MGMagnesium ionMg2
ANPPhosphoaminophosphonic acid-adenylate esterC10 H17 N6 O12 P32

Primary citation

Structure of the human ATM kinase and mechanism of Nbs1 binding. Warren, C., Pavletich, N.P. Elife (2022) 11. DOI 10.7554/eLife.74218 · PubMed

Other PDB entries of the same protein (UniProt Q13315), best resolution first:

Browse structure collections

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