8OXQ: ATM(Q2971A) dimeric C-terminal region

ATM(Q2971A) dimeric C-terminal region in complex with Mg AMP-PNP. Determined by electron microscopy at 2.5 Å resolution. Released 27 Sept 2023.

Method
Electron microscopy
Resolution
2.5 Å
Organism
Homo sapiens
Chains
2
Atoms
25,078
Mol. weight
731.2 kDa
Ligands
ANP, ZN, MG
Released
27 Sept 2023

Explore 8OXQ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8OXQ contains 180 α-helices and 32 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and B: 90 helices, 16 β-strands

ElementResiduesLengthSheet
α-helix1413-142816
α-helix1432-145019
α-helix1461-147717
α-helix1485-150824
α-helix1513-15153
α-helix1517-152711
α-helix1532-154211
α-helix1543-15475
α-helix1553-15608
α-helix1563-15664
α-helix1572-158211
α-helix1590-160112
α-helix1607-16104
α-helix1611-162313
α-helix1625-163410
α-helix1643-165816
α-helix1664-167714
β-strand168711
α-helix1694-17029
α-helix1706-172116
α-helix1727-174216
α-helix1744-175310
α-helix1759-17635
α-helix1792-17954
α-helix1802-181514
α-helix1822-18254
α-helix1828-18314
α-helix1835-185117
α-helix1857-187418
α-helix1903-191715
α-helix1920-19212
α-helix1927-19304
α-helix1938-194710
α-helix1951-197323
α-helix1986-199712
α-helix2001-201212
α-helix2016-20194
α-helix2029-203810
α-helix2042-205110
α-helix2057-207014
α-helix2074-208714
α-helix2093-210513
α-helix2124-213613
α-helix2140-215920
β-strand216511
α-helix2166-21683
α-helix2170-219021
α-helix2195-221016
α-helix2217-223620
α-helix2245-226420
α-helix2269-228113
α-helix2290-230112
α-helix2305-232218
α-helix2328-234821
α-helix2353-23564
α-helix2357-23615
α-helix2362-23709
α-helix2377-240630
α-helix2408-242114
α-helix2437-247539
α-helix2481-24833
α-helix2484-249310
α-helix2498-250710
α-helix2508-25103
α-helix2513-25164
α-helix2520-25256
α-helix2537-255115
α-helix2553-256412
α-helix2568-25725
α-helix2593-261220
α-helix2614-263219
α-helix2637-26404
β-strand2645-264622
α-helix2647-26482
β-strand2659-266353
α-helix2668-26714
β-strand2682-268653
β-strand2689-269022
β-strand2691-269223
β-strand2700-270673
β-strand2711-271773
α-helix2723-274018
α-helix2743-27486
β-strand2757-275933
β-strand2765-276843
β-strand2773-277534
α-helix2776-27805
α-helix2787-27915
α-helix2798-280710
α-helix2808-28103
α-helix2813-282513
α-helix2833-28386
α-helix2842-286625
α-helix2873-28753
β-strand2876-287944
β-strand2885-288734
α-helix2912-29165
α-helix2926-294015
α-helix2942-295312
α-helix2964-29707
α-helix3002-301716
β-strand302015
β-strand302515
α-helix3028-304013
α-helix3042-30476
α-helix3050-30523

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Serine-protein kinase ATMA, Bprotein3184Homo sapiensQ13315
Sequence of entity 1 (A, B), FASTA
>8OXQ_1 Serine-protein kinase ATM (chains A, B)
MDYKDDDDKHMGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFM
LGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLEGG
SAGSGSASMSLVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSKQG
KYLNWDAVFRFLQKYIQKETECLRIAKPNVSASTQASRQKKMQEISSLVKYFIKCANRRA
PRLKCQELLNYIMDTVKDSSNGAIYGADCSNILLKDILSVRKYWCEISQQQWLELFSVYF
RLYLKPSQDVHRVLVARIIHAVTKGCCSQTDGLNSKFLDFFSKAIQCARQEKSSSGLNHI
LAALTIFLKTLAVNFRIRVCELGDEILPTLLYIWTQHRLNDSLKEVIIELFQLQIYIHHP
KGAKTQEKGAYESTKWRSILYNLYDLLVNEISHIGSRGKYSSGFRNIAVKENLIELMADI
CHQVFNEDTRSLEISQSYTTTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQNDFDLVPW
LQIATQLISKYPASLPNCELSPLLMILSQLLPQQRHGERTPYVLRCLTEVALCQDKRSNL
ESSQKSDLLKLWNKIWCITFRGISSEQIQAENFGLLGAIIQGSLVEVDREFWKLFTGSAC
RPSCPAVCCLTLALTTSIVPGTVKMGIEQNMCEVNRSFSLKESIMKWLLFYQLEGDLENS
TEVPPILHSNFPHLVLEKILVSLTMKNCKAAMNFFQSVPECEHHQKDKEELSFSEVEELF
LQTTFDKMDFLTIVRECGIEKHQSSIGFSVHQNLKESLDRCLLGLSEQLLNNYSSEITNS
ETLVRCSRLLVGVLGCYCYMGVIAEEEAYKSELFQKAKSLMQCAGESITLFKNKTNEEFR
IGSLRNMMQLCTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDIADICKSLASFIKKPFDR
GEVESMEDDTNGNLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTIGAINPLAEEYLSK
QDLLFLDMLKFLCLCVTTAQTNTVSFRAADIRRKLLMLIDSSTLEPTKSLHLHMYLMLLK
ELPGEEYPLPMEDVLELLKPLSNVCSLYRRDQDVCKTILNHVLHVVKNLGQSNMDSENTR
DAQGQFLTVIGAFWHLTKERKYIFSVRMALVNCLKTLLEADPYSKWAILNVMGKDFPVNE
VFTQFLADNHHQVRMLAAESINRLFQDTKGDSSRLLKALPLKLQQTAFENAYLKAQEGMR
EMSHSAENPETLDEIYNRKSVLLTLIAVVLSCSPICEKQALFALCKSVKENGLEPHLVKK
VLEKVSETFGYRRLEDFMASHLDYLVLEWLNLQDTEYNLSSFPFILLNYTNIEDFYRSCY
KVLIPHLVIRSHFDEVKSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDSGMAQQR
ETATKVYDMLKSENLLGKQIDHLFISNLPEIVVELLMTLHEPANSSASQSTDLCDFSGDL
DPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEILSKSPDSYQKILLAICEQAAETNNV
YKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQRPSCIMDVSLRSFS
LCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDN
ENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLE
GLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVG
SCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSA
AVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDI
NLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQ
DTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPANLDSESEHFFRCCLDKKSQRTMLAV
VDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEK
RSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITR
LRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKDWC
PELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARV
KEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLL
KDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPE
RAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKL
TYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLAR
FSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELAL
RALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIP
TYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFL
TKPEVARRSRITKNVPKQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILAN
LDATQWKTQRKGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRL
AGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTI
CTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKS
FEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRH
VQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCE
KTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLAQRPEDETELHPTLNADDQECK
RNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGW
KAWV

Ligands and cofactors

IDNameFormulaCopies
ANPPhosphoaminophosphonic acid-adenylate esterC10 H17 N6 O12 P32
ZNZinc ionZn2
MGMagnesium ionMg2

Primary citation

Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress. Howes, A.C., Perisic, O., Williams, R.L. Sci Adv (2023) 9:eadi8291-eadi8291. DOI 10.1126/sciadv.adi8291 · PubMed

Other PDB entries of the same protein (UniProt Q13315), best resolution first:

Browse structure collections

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