6K9L: Serine-protein kinase ATM

4.27 Angstrom resolution cryo-EM structure of human dimeric ATM kinase. Determined by electron microscopy at 4.27 Å resolution. Released 25 Dec 2019.

Method
Electron microscopy
Resolution
4.27 Å
Organism
Homo sapiens
Chains
2
Atoms
30,601
Mol. weight
702.26 kDa
Released
25 Dec 2019

Explore 6K9L in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6K9L contains 325 α-helices and 20 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 164 helices, 10 β-strands

ElementResiduesLengthSheet
α-helix6-1510
α-helix25-3511
α-helix40-434
α-helix60-656
α-helix69-779
α-helix95-10814
α-helix118-1269
α-helix148-1536
α-helix158-1614
α-helix167-17610
α-helix183-19513
α-helix196-2005
α-helix205-2073
α-helix209-2179
α-helix224-2274
α-helix230-2367
α-helix250-2578
α-helix264-28724
α-helix306-32419
α-helix339-35618
α-helix412-42110
α-helix433-44917
α-helix457-46610
α-helix482-49211
α-helix498-51417
α-helix520-5223
α-helix524-5296
α-helix538-5403
α-helix541-5455
α-helix558-5658
α-helix577-58610
α-helix587-5893
α-helix604-6085
α-helix609-6146
α-helix624-63714
α-helix647-6515
α-helix658-6625
α-helix686-69611
α-helix698-7047
α-helix712-72110
α-helix731-7366
α-helix737-7415
α-helix748-76013
α-helix831-8377
α-helix844-86017
α-helix879-8879
α-helix924-9318
α-helix948-95811
α-helix967-98115
α-helix990-100415
α-helix1014-10196
α-helix1036-10383
α-helix1043-10486
α-helix1059-10657
α-helix1071-108818
α-helix1106-112520
α-helix1133-114210
α-helix1150-11578
α-helix1165-11695
α-helix1171-11744
α-helix1195-11973
α-helix1198-12014
α-helix1213-12175
α-helix1218-12214
α-helix1237-12437
α-helix1255-127016
α-helix1277-12815
α-helix1282-12843
α-helix1295-12973
α-helix1302-13065
α-helix1342-13443
α-helix1354-13574
α-helix1366-13727
α-helix1382-13854
α-helix1396-13983
α-helix1418-14225
α-helix1437-144812
α-helix1458-147316
α-helix1478-14825
α-helix1485-149814
α-helix1515-15217
α-helix1532-15343
α-helix1535-15439
α-helix1550-15556
α-helix1558-15625
α-helix1570-15756
α-helix1576-15838
α-helix1592-160211
α-helix1612-16187
α-helix1630-16334
α-helix1634-16407
α-helix1641-165010
α-helix1658-167215
α-helix1678-16836
α-helix1703-17075
α-helix1715-172612
α-helix1736-17383
α-helix1739-17435
α-helix1749-17513
α-helix1752-17554
α-helix1761-17633
α-helix1764-17685
α-helix1823-18264
α-helix1827-18359
α-helix1842-18465
α-helix1856-187419
α-helix1878-189114
α-helix1905-19128
α-helix1927-19337
α-helix1938-194811
α-helix1952-196817
α-helix2000-201213
α-helix2015-20217
α-helix2043-20475
α-helix2056-20583
α-helix2060-207112
α-helix2076-20838
α-helix2096-20994
α-helix2124-213411
α-helix2141-215111
α-helix2155-21606
α-helix2170-219021
α-helix2195-221016
α-helix2211-22144
α-helix2221-223212
α-helix2233-22353
α-helix2241-22433
α-helix2244-226320
α-helix2269-22779
α-helix2278-22825
α-helix2292-230110
α-helix2308-232114
α-helix2329-234820
α-helix2377-241943
α-helix2438-247336
α-helix2481-24833
α-helix2486-24894
α-helix2500-25023
α-helix2504-25074
α-helix2517-25193
α-helix2520-25278
α-helix2537-255115
α-helix2553-256412
α-helix2595-261218
α-helix2617-263317
α-helix2636-26394
α-helix2654-26585
β-strand266211
β-strand268311
β-strand2687-269152
β-strand2700-270562
β-strand2711-271882
α-helix2724-27274
α-helix2730-274112
α-helix2744-27463
β-strand2757-275932
β-strand2764-276962
β-strand2773-277533
α-helix2776-27794
α-helix2787-27904
α-helix2799-280810
α-helix2816-282510
α-helix2831-28344
α-helix2842-286625
β-strand2876-287943
β-strand2885-288733
α-helix2912-29176
α-helix2923-29275
α-helix2928-29358
α-helix2942-295211
α-helix2972-29787
α-helix3000-301617
α-helix3028-303710
α-helix3042-30454
Chain B: 161 helices, 10 β-strands
ElementResiduesLengthSheet
α-helix3-1513
α-helix25-3511
α-helix40-434
α-helix60-656
α-helix69-779
α-helix95-10814
α-helix118-12811
α-helix148-1536
α-helix167-17610
α-helix183-19513
α-helix196-2005
α-helix205-2073
α-helix209-2179
α-helix224-2274
α-helix230-2367
α-helix250-2578
α-helix264-27310
α-helix274-2785
α-helix279-2879
α-helix306-31914
α-helix320-3223
α-helix340-3445
α-helix346-35510
α-helix413-4197
α-helix433-44816
α-helix458-46811
α-helix476-49116
α-helix498-51417
α-helix524-5307
α-helix538-5403
α-helix541-5455
α-helix558-5658
α-helix577-58610
α-helix587-5893
α-helix604-6085
α-helix609-6146
α-helix624-63714
α-helix647-6515
α-helix658-6625
α-helix686-69611
α-helix698-7047
α-helix712-7209
α-helix731-7344
α-helix748-76013
α-helix831-8344
α-helix844-85916
α-helix879-8879
α-helix924-9318
α-helix948-95811
α-helix967-98115
α-helix990-100415
α-helix1014-10196
α-helix1036-10383
α-helix1043-10486
α-helix1059-10657
α-helix1071-108818
α-helix1106-11149
α-helix1116-112510
α-helix1133-114210
α-helix1150-11578
α-helix1165-11695
α-helix1171-11744
α-helix1194-12018
α-helix1213-12175
α-helix1218-12214
α-helix1237-12437
α-helix1255-127016
α-helix1277-12815
α-helix1282-12843
α-helix1295-12973
α-helix1302-13065
α-helix1354-13574
α-helix1366-13727
α-helix1382-13854
α-helix1396-13994
α-helix1418-14225
α-helix1437-144812
α-helix1458-147316
α-helix1478-14825
α-helix1485-150016
α-helix1515-15217
α-helix1532-15343
α-helix1535-15439
α-helix1550-15556
α-helix1558-15625
α-helix1570-15756
α-helix1576-15838
α-helix1592-160211
α-helix1612-16187
α-helix1630-16334
α-helix1634-16407
α-helix1641-165010
α-helix1658-167215
α-helix1678-16836
α-helix1706-17094
α-helix1714-172512
α-helix1734-17385
α-helix1739-17435
α-helix1749-17513
α-helix1752-17554
α-helix1761-17633
α-helix1764-17685
α-helix1823-18264
α-helix1827-18359
α-helix1842-18465
α-helix1856-187419
α-helix1878-189114
α-helix1905-19128
α-helix1927-19337
α-helix1938-194811
α-helix1952-196817
α-helix2000-201213
α-helix2015-20217
α-helix2058-207114
α-helix2076-20838
α-helix2096-20994
α-helix2124-213411
α-helix2141-215919
α-helix2170-218920
α-helix2195-221016
α-helix2211-22144
α-helix2221-223212
α-helix2233-22353
α-helix2241-22433
α-helix2244-226320
α-helix2269-228012
α-helix2292-230110
α-helix2307-232115
α-helix2329-234820
α-helix2377-241943
α-helix2438-247336
α-helix2481-24833
α-helix2486-24894
α-helix2500-25023
α-helix2504-25074
α-helix2517-25193
α-helix2520-25278
α-helix2537-255115
α-helix2553-256412
α-helix2595-261218
α-helix2617-263317
α-helix2636-26394
α-helix2654-26585
β-strand266214
β-strand268314
β-strand2687-269155
β-strand2700-270565
β-strand2711-271885
α-helix2724-27274
α-helix2730-274112
α-helix2744-27463
α-helix2751-27533
β-strand2757-275935
β-strand2764-276965
β-strand2773-277536
α-helix2776-27794
α-helix2787-27904
α-helix2799-280810
α-helix2816-282510
α-helix2831-28344
α-helix2842-286625
β-strand2876-287946
β-strand2885-288736
α-helix2912-29176
α-helix2923-29275
α-helix2928-29358
α-helix2942-295211
α-helix2972-29787
α-helix3000-301617
α-helix3028-303710
α-helix3042-30454

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Serine-protein kinase ATMA, Bprotein3056Homo sapiensQ13315
Sequence of entity 1 (A, B), FASTA
>6K9L_1 Serine-protein kinase ATM (chains A, B)
MSLVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSKQGKYLNWDAV
FRFLQKYIQKETECLRIAKPNVSASTQASRQKKMQEISSLVKYFIKCANRRAPRLKCQEL
LNYIMDTVKDSSNGAIYGADCSNILLKDILSVRKYWCEISQQQWLELFSVYFRLYLKPSQ
DVHRVLVARIIHAVTKGCCSQTDGLNSKFLDFFSKAIQCARQEKSSSGLNHILAALTIFL
KTLAVNFRIRVCELGDEILPTLLYIWTQHRLNDSLKEVIIELFQLQIYIHHPKGAKTQEK
GAYESTKWRSILYNLYDLLVNEISHIGSRGKYSSGFRNIAVKENLIELMADICHQVFNED
TRSLEISQSYTTTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQNDFDLVPWLQIATQLI
SKYPASLPNCELSPLLMILSQLLPQQRHGERTPYVLRCLTEVALCQDKRSNLESSQKSDL
LKLWNKIWCITFRGISSEQIQAENFGLLGAIIQGSLVEVDREFWKLFTGSACRPSCPAVC
CLTLALTTSIVPGTVKMGIEQNMCEVNRSFSLKESIMKWLLFYQLEGDLENSTEVPPILH
SNFPHLVLEKILVSLTMKNCKAAMNFFQSVPECEHHQKDKEELSFSEVEELFLQTTFDKM
DFLTIVRECGIEKHQSSIGFSVHQNLKESLDRCLLGLSEQLLNNYSSEITNSETLVRCSR
LLVGVLGCYCYMGVIAEEEAYKSELFQKAKSLMQCAGESITLFKNKTNEEFRIGSLRNMM
QLCTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDIADICKSLASFIKKPFDRGEVESMED
DTNGNLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTIGAINPLAEEYLSKQDLLFLDM
LKFLCLCVTTAQTNTVSFRAADIRRKLLMLIDSSTLEPTKSLHLHMYLMLLKELPGEEYP
LPMEDVLELLKPLSNVCSLYRRDQDVCKTILNHVLHVVKNLGQSNMDSENTRDAQGQFLT
VIGAFWHLTKERKYIFSVRMALVNCLKTLLEADPYSKWAILNVMGKDFPVNEVFTQFLAD
NHHQVRMLAAESINRLFQDTKGDSSRLLKALPLKLQQTAFENAYLKAQEGMREMSHSAEN
PETLDEIYNRKSVLLTLIAVVLSCSPICEKQALFALCKSVKENGLEPHLVKKVLEKVSET
FGYRRLEDFMASHLDYLVLEWLNLQDTEYNLSSFPFILLNYTNIEDFYRSCYKVLIPHLV
IRSHFDEVKSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDSGMAQQRETATKVYD
MLKSENLLGKQIDHLFISNLPEIVVELLMTLHEPANSSASQSTDLCDFSGDLDPAPNPPH
FPSHVIKATFAYISNCHKTKLKSILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILK
IYHLFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQ
VCQTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDNENLYITIK
LLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQ
LELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVGSCLGEVGP
IDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNI
LATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDINLWIPLSE
NHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRN
LLSTHVQGFFTSCLRHFSQTSRSTTPANLDSESEHFFRCCLDKKSQRTMLAVVDYMRRQK
RPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKRSLAFEEG
SQSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEA
MWGKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHY
QAAWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCK
RSLESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQ
EPIMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQ
YNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRV
CGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDTQYQR
IENYMKSSEFENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRK
RFLCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLM
YQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVARR
SRITKNVPKQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKT
QRKGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPK
IIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPL
SQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVF
MDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINE
QSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRN
SQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQ
SFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV

Primary citation

Structural insights into the activation of ATM kinase. Xiao, J., Liu, M., Qi, Y. et al. Cell Res (2019) 29:683-685. DOI 10.1038/s41422-019-0205-0 · PubMed

Other PDB entries of the same protein (UniProt Q13315), best resolution first:

Browse structure collections

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