6K9K: Serine-protein kinase ATM

Monomeric human ATM (Ataxia telangiectasia mutated) kinase. Determined by electron microscopy at 7.82 Å resolution. Released 25 Dec 2019.

Method
Electron microscopy
Resolution
7.82 Å
Organism
Homo sapiens
Chains
1
Atoms
16,507
Mol. weight
351.13 kDa
Released
25 Dec 2019

Explore 6K9K in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6K9K contains 140 α-helices and 9 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 140 helices, 9 β-strands

ElementResiduesLengthSheet
α-helix8-1710
α-helix25-339
α-helix35-395
α-helix45-6420
α-helix94-10916
α-helix116-12914
α-helix135-15622
α-helix157-1593
α-helix164-17411
α-helix184-19916
α-helix207-22014
α-helix227-23610
α-helix246-25813
α-helix266-28116
α-helix306-32318
α-helix337-35620
α-helix412-42110
α-helix433-44917
α-helix454-46714
α-helix475-49016
α-helix501-51313
α-helix519-53214
α-helix539-54810
α-helix558-5669
α-helix577-58711
α-helix605-61410
α-helix620-64122
α-helix647-66014
α-helix682-6887
α-helix692-70615
α-helix709-72416
α-helix731-74212
α-helix745-76319
α-helix831-8388
α-helix841-86020
α-helix876-88914
α-helix921-93212
α-helix940-95819
α-helix967-97812
α-helix988-100821
α-helix1014-102815
α-helix1031-10344
α-helix1038-105215
α-helix1056-107015
α-helix1076-109217
α-helix1103-112422
α-helix1127-113812
α-helix1144-116017
α-helix1164-118320
α-helix1189-120113
α-helix1210-122011
α-helix1237-124610
α-helix1252-126918
α-helix1275-128915
α-helix1295-13017
α-helix1303-131513
α-helix1342-13454
α-helix1354-13574
α-helix1366-13727
α-helix1380-13889
α-helix1402-14065
α-helix1411-142212
α-helix1426-14338
α-helix1437-144812
α-helix1458-147316
α-helix1479-14824
α-helix1485-150117
α-helix1508-152417
α-helix1532-154110
α-helix1550-156011
α-helix1569-158113
α-helix1593-160513
α-helix1611-162111
α-helix1630-16378
α-helix1642-16498
α-helix1650-16523
α-helix1659-166810
α-helix1678-16825
α-helix1704-17074
α-helix1714-172613
α-helix1734-17418
α-helix1746-17472
α-helix1748-17525
α-helix1761-17633
α-helix1766-17683
α-helix1805-181511
α-helix1823-183412
α-helix1842-18509
α-helix1856-187318
α-helix1885-189410
α-helix1902-19076
α-helix1909-19157
α-helix1926-19338
α-helix1942-19487
α-helix1951-197525
α-helix2001-201212
α-helix2015-20184
α-helix2125-213410
α-helix2143-216018
α-helix2170-218819
α-helix2197-221115
α-helix2217-223620
α-helix2243-226523
α-helix2270-228011
α-helix2282-22843
α-helix2291-22944
α-helix2296-22983
α-helix2309-231911
α-helix2323-23264
α-helix2332-234817
α-helix2353-237018
α-helix2378-23825
α-helix2383-241836
α-helix2441-247636
α-helix2481-249313
α-helix2499-25079
α-helix2513-252614
α-helix2538-254811
α-helix2556-25649
α-helix2597-261014
α-helix2617-263822
α-helix2654-26618
α-helix2690-26912
β-strand269211
β-strand2700-270561
β-strand2711-271881
α-helix2723-27253
α-helix2727-274115
α-helix2744-27474
β-strand276111
β-strand2764-276851
β-strand2774-277522
α-helix2777-27826
α-helix2783-27875
α-helix2794-281017
α-helix2816-283621
α-helix2845-286622
β-strand287613
β-strand2877-287822
β-strand288713
α-helix2895-28984
α-helix2911-29177
α-helix2923-293816
α-helix2942-295211
α-helix2966-297712
α-helix2999-301416
α-helix3028-304013
α-helix3042-30476
α-helix3050-30545

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Serine-protein kinase ATMAprotein3056Homo sapiensQ13315
Sequence of entity 1 (A), FASTA
>6K9K_1 Serine-protein kinase ATM (chains A)
MSLVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSKQGKYLNWDAV
FRFLQKYIQKETECLRIAKPNVSASTQASRQKKMQEISSLVKYFIKCANRRAPRLKCQEL
LNYIMDTVKDSSNGAIYGADCSNILLKDILSVRKYWCEISQQQWLELFSVYFRLYLKPSQ
DVHRVLVARIIHAVTKGCCSQTDGLNSKFLDFFSKAIQCARQEKSSSGLNHILAALTIFL
KTLAVNFRIRVCELGDEILPTLLYIWTQHRLNDSLKEVIIELFQLQIYIHHPKGAKTQEK
GAYESTKWRSILYNLYDLLVNEISHIGSRGKYSSGFRNIAVKENLIELMADICHQVFNED
TRSLEISQSYTTTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQNDFDLVPWLQIATQLI
SKYPASLPNCELSPLLMILSQLLPQQRHGERTPYVLRCLTEVALCQDKRSNLESSQKSDL
LKLWNKIWCITFRGISSEQIQAENFGLLGAIIQGSLVEVDREFWKLFTGSACRPSCPAVC
CLTLALTTSIVPGTVKMGIEQNMCEVNRSFSLKESIMKWLLFYQLEGDLENSTEVPPILH
SNFPHLVLEKILVSLTMKNCKAAMNFFQSVPECEHHQKDKEELSFSEVEELFLQTTFDKM
DFLTIVRECGIEKHQSSIGFSVHQNLKESLDRCLLGLSEQLLNNYSSEITNSETLVRCSR
LLVGVLGCYCYMGVIAEEEAYKSELFQKAKSLMQCAGESITLFKNKTNEEFRIGSLRNMM
QLCTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDIADICKSLASFIKKPFDRGEVESMED
DTNGNLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTIGAINPLAEEYLSKQDLLFLDM
LKFLCLCVTTAQTNTVSFRAADIRRKLLMLIDSSTLEPTKSLHLHMYLMLLKELPGEEYP
LPMEDVLELLKPLSNVCSLYRRDQDVCKTILNHVLHVVKNLGQSNMDSENTRDAQGQFLT
VIGAFWHLTKERKYIFSVRMALVNCLKTLLEADPYSKWAILNVMGKDFPVNEVFTQFLAD
NHHQVRMLAAESINRLFQDTKGDSSRLLKALPLKLQQTAFENAYLKAQEGMREMSHSAEN
PETLDEIYNRKSVLLTLIAVVLSCSPICEKQALFALCKSVKENGLEPHLVKKVLEKVSET
FGYRRLEDFMASHLDYLVLEWLNLQDTEYNLSSFPFILLNYTNIEDFYRSCYKVLIPHLV
IRSHFDEVKSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDSGMAQQRETATKVYD
MLKSENLLGKQIDHLFISNLPEIVVELLMTLHEPANSSASQSTDLCDFSGDLDPAPNPPH
FPSHVIKATFAYISNCHKTKLKSILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILK
IYHLFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQ
VCQTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDNENLYITIK
LLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQ
LELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVGSCLGEVGP
IDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNI
LATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDINLWIPLSE
NHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRN
LLSTHVQGFFTSCLRHFSQTSRSTTPANLDSESEHFFRCCLDKKSQRTMLAVVDYMRRQK
RPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKRSLAFEEG
SQSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEA
MWGKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHY
QAAWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCK
RSLESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQ
EPIMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQ
YNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRV
CGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDTQYQR
IENYMKSSEFENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRK
RFLCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLM
YQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVARR
SRITKNVPKQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKT
QRKGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPK
IIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPL
SQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVF
MDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINE
QSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRN
SQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQ
SFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV

Primary citation

Structural insights into the activation of ATM kinase. Xiao, J., Liu, M., Qi, Y. et al. Cell Res (2019) 29:683-685. DOI 10.1038/s41422-019-0205-0 · PubMed

Other PDB entries of the same protein (UniProt Q13315), best resolution first:

Browse structure collections

About this viewer

MolViewer shows 6K9K directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.