5NP1: Open protomer of human ATM

Open protomer of human ATM (Ataxia telangiectasia mutated). Determined by electron microscopy at 5.7 Å resolution. Released 17 May 2017.

Method
Electron microscopy
Resolution
5.7 Å
Organism
Homo sapiens
Chains
1
Atoms
12,201
Mol. weight
352.39 kDa
Released
17 May 2017

Explore 5NP1 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5NP1 contains 180 α-helices and 10 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 180 helices, 10 β-strands

ElementResiduesLengthSheet
α-helix4-1613
α-helix22-3514
α-helix39-446
α-helix59-657
α-helix68-7710
α-helix95-10915
α-helix116-12510
α-helix147-1548
α-helix157-1615
α-helix168-1769
α-helix184-19714
α-helix205-2073
α-helix208-21710
α-helix224-23714
α-helix243-2464
α-helix250-2589
α-helix264-2729
α-helix277-2826
α-helix306-32116
α-helix340-35516
α-helix413-4197
α-helix433-44917
α-helix455-46915
α-helix475-49117
α-helix498-51417
α-helix520-52910
α-helix538-5403
α-helix541-5455
α-helix558-5669
α-helix572-5743
α-helix579-5857
α-helix586-5883
α-helix604-6063
α-helix609-6146
α-helix624-63714
α-helix647-6515
α-helix654-6563
α-helix683-6853
α-helix686-70621
α-helix711-72010
α-helix731-7399
α-helix748-76013
α-helix824-8263
α-helix827-83610
α-helix844-86017
α-helix878-88710
α-helix923-93210
α-helix945-9484
α-helix949-95810
α-helix967-9693
α-helix970-98112
α-helix991-100111
α-helix1015-10195
α-helix1043-10486
α-helix1057-10626
α-helix1071-108717
α-helix1088-10903
α-helix1106-11105
α-helix1111-11166
α-helix1117-11259
α-helix1133-114210
α-helix1146-11483
α-helix1150-11589
α-helix1165-11695
α-helix1171-11744
α-helix1195-11995
α-helix1214-12218
α-helix1238-12469
α-helix1255-126814
α-helix1277-12815
α-helix1282-12909
α-helix1295-12995
α-helix1302-13065
α-helix1335-13373
α-helix1342-13465
α-helix1357-13593
α-helix1363-13675
α-helix1368-13725
α-helix1377-13804
α-helix1383-13875
α-helix1418-14236
α-helix1429-14335
α-helix1437-144812
α-helix1457-147418
α-helix1478-14814
α-helix1484-150017
α-helix1515-15206
α-helix1521-15233
α-helix1526-15294
α-helix1532-154211
α-helix1551-15566
α-helix1558-15625
α-helix1570-15756
α-helix1579-15824
α-helix1592-160312
α-helix1610-16189
α-helix1619-16224
α-helix1632-164817
α-helix1658-166811
α-helix1679-16824
α-helix1702-17087
α-helix1714-172512
α-helix1733-17353
α-helix1736-17449
α-helix1746-175510
α-helix1760-17689
α-helix1807-18093
α-helix1812-18154
α-helix1823-183513
α-helix1842-18454
α-helix1848-18525
α-helix1856-187318
α-helix1877-189317
α-helix1903-191412
α-helix1926-19338
α-helix1938-194811
α-helix1951-197525
α-helix1999-201214
α-helix2015-20228
α-helix2075-208511
α-helix2096-210510
α-helix2108-21114
α-helix2112-21154
α-helix2124-213411
α-helix2142-215918
α-helix2169-219022
α-helix2196-221217
α-helix2217-22204
α-helix2222-223716
α-helix2238-22403
α-helix2242-226524
α-helix2269-228012
α-helix2282-22843
α-helix2292-22965
α-helix2297-23004
α-helix2309-232315
α-helix2329-234820
α-helix2353-23564
α-helix2359-23679
α-helix2377-23837
α-helix2384-23885
α-helix2389-240315
α-helix2406-24127
α-helix2450-24578
α-helix2458-24636
α-helix2464-247613
α-helix2481-24833
α-helix2484-249411
α-helix2499-25068
α-helix2507-25104
α-helix2513-25164
α-helix2517-25193
α-helix2520-25278
α-helix2538-255013
α-helix2553-256513
α-helix2598-261215
α-helix2618-263114
α-helix2659-26613
β-strand268711
β-strand269211
α-helix2698-26992
β-strand2700-270561
β-strand2711-271661
α-helix2722-274120
α-helix2743-27486
β-strand275812
β-strand276612
β-strand277313
α-helix2778-27836
α-helix2784-27885
α-helix2794-28007
α-helix2801-28033
α-helix2814-282613
α-helix2830-28323
α-helix2833-28386
α-helix2843-286624
β-strand287713
β-strand287914
β-strand288414
α-helix2895-28995
α-helix2911-29177
α-helix2923-29253
α-helix2927-294014
α-helix2944-295310
α-helix2956-29594
α-helix2966-29694
α-helix2999-301618
α-helix3028-303912
α-helix3042-30476
α-helix3050-30534

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Serine-protein kinase ATMAprotein3066Homo sapiensQ13315
Sequence of entity 1 (A), FASTA
>5NP1_1 Serine-protein kinase ATM (chains A)
MDYKDDDDKHMSLVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSK
QGKYLNWDAVFRFLQKYIQKETECLRIAKPNVSASTQASRQKKMQEISSLVKYFIKCANR
RAPRLKCQELLNYIMDTVKDSSNGAIYGADCSNILLKDILSVRKYWCEISQQQWLELFSV
YFRLYLKPSQDVHRVLVARIIHAVTKGCCSQTDGLNSKFLDFFSKAIQCARQEKSSSGLN
HILAALTIFLKTLAVNFRIRVCELGDEILPTLLYIWTQHRLNDSLKEVIIELFQLQIYIH
HPKGAKTQEKGAYESTKWRSILYNLYDLLVNEISHIGSRGKYSSGFRNIAVKENLIELMA
DICHQVFNEDTRSLEISQSYTTTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQNDFDLV
PWLQIATQLISKYPASLPNCELSPLLMILSQLLPQQRHGERTPYVLRCLTEVALCQDKRS
NLESSQKSDLLKLWNKIWCITFRGISSEQIQAENFGLLGAIIQGSLVEVDREFWKLFTGS
ACRPSCPAVCCLTLALTTSIVPGTVKMGIEQNMCEVNRSFSLKESIMKWLLFYQLEGDLE
NSTEVPPILHSNFPHLVLEKILVSLTMKNCKAAMNFFQSVPECEHHQKDKEELSFSEVEE
LFLQTTFDKMDFLTIVRECGIEKHQSSIGFSVHQNLKESLDRCLLGLSEQLLNNYSSEIT
NSETLVRCSRLLVGVLGCYCYMGVIAEEEAYKSELFQKAKSLMQCAGESITLFKNKTNEE
FRIGSLRNMMQLCTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDIADICKSLASFIKKPF
DRGEVESMEDDTNGNLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTIGAINPLAEEYL
SKQDLLFLDMLKFLCLCVTTAQTNTVSFRAADIRRKLLMLIDSSTLEPTKSLHLHMYLML
LKELPGEEYPLPMEDVLELLKPLSNVCSLYRRDQDVCKTILNHVLHVVKNLGQSNMDSEN
TRDAQGQFLTVIGAFWHLTKERKYIFSVRMALVNCLKTLLEADPYSKWAILNVMGKDFPV
NEVFTQFLADNHHQVRMLAAESINRLFQDTKGDSSRLLKALPLKLQQTAFENAYLKAQEG
MREMSHSAENPETLDEIYNRKSVLLTLIAVVLSCSPICEKQALFALCKSVKENGLEPHLV
KKVLEKVSETFGYRRLEDFMASHLDYLVLEWLNLQDTEYNLSSFPFILLNYTNIEDFYRS
CYKVLIPHLVIRSHFDEVKSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDSGMAQ
QRETATKVYDMLKSENLLGKQIDHLFISNLPEIVVELLMTLHEPANSSASQSTDLCDFSG
DLDPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEILSKSPDSYQKILLAICEQAAETN
NVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQRPSCIMDVSLRS
FSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNK
DNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTR
LEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEA
VGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVR
SAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLD
DINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDIL
LQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPANLDSESEHFFRCCLDKKSQRTML
AVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQ
EKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPI
TRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKD
WCPELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYA
RVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQ
LLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQL
PERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSL
KLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSL
ARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDEL
ALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMK
IPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDE
FLTKPEVARRSRITKNVPKQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIIL
ANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEF
RLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKL
TICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQK
KSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGD
RHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRC
CEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQE
CKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFP
GWKAWV

Primary citation

Structures of closed and open conformations of dimeric human ATM. Baretic, D., Pollard, H.K., Fisher, D.I. et al. Sci Adv (2017) 3:e1700933-e1700933. DOI 10.1126/sciadv.1700933 · PubMed

Other PDB entries of the same protein (UniProt Q13315), best resolution first:

Browse structure collections

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