Transcription elongation regulator 1 (TCERG1) is a 1098-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O14776.
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The mean pLDDT of this model is 67.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 28% |
| 70 to 90 | Confident: backbone generally right | 32% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 36% |
What pLDDT means and how to read it
Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter
Binds formin (By similarity). Interacts (via the second WW domain) with TREX1 (via proline-rich region) (By similarity). Binds RNA polymerase II, HD and SF1
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3Q1I | X-ray | 1.4 Å | E=99-107 |
| 4FQG | X-ray | 2.0 Å | A/B=895-1081 |
| 3HFH | X-ray | 2.7 Å | A/B=661-845 |
| 8Q7N | EM | 3.1 Å | T=1-1098 |
| 7ABF | EM | 3.9 Å | A4=1-1098 |
| 8QO9 | EM | 5.29 Å | T=1-1098 |
| 7ABG | EM | 7.8 Å | A4=1-1098 |
| 2DK7 | NMR | A=520-579 | |
| 2DOD | NMR | A=651-719 | |
| 2DOE | NMR | A=784-853 | |
| 2DOF | NMR | A=888-959 | |
| 2E71 | NMR | A=717-786 | |
| 2KIQ | NMR | A=724-782 | |
| 2KIS | NMR | A=659-724 | |
| 2MW9 | NMR | A=428-464 | |
| 2MWA | NMR | A=428-464 | |
| 2MWB | NMR | A=428-464 | |
| 2MWD | NMR | A=433-460 | |
| 2MWE | NMR | A=433-460 | |
| 2MWF | NMR | A=433-464 |
Showing 20 of 27 experimental structures (best resolution first).
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