2MWD: FBP28 WW2 mutant Y438R DNDC

NMR structure of FBP28 WW2 mutant Y438R DNDC. Determined by solution NMR. Released 3 Dec 2014.

Method: Solution NMR
Organism: Homo sapiens
Chains: 1
Atoms: 245
Mol. weight: 3.46 kDa
Released: 3 Dec 2014

Explore 2MWD in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2MWD contains 0 α-helices and 3 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 0 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	436-440	5	1
β-strand	444-449	6	1
β-strand	454-456	3	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Transcription elongation regulator 1	A	protein	28	Homo sapiens	O14776 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2MWD_1 Transcription elongation regulator 1 (chains A)
SEWTERKTADGKTYYYNNRTLESTWEKP

Primary citation

Folding kinetics of WW domains with the united residue force field for bridging microscopic motions and experimental measurements. Zhou, R., Maisuradze, G.G., Sunol, D. et al. Proc Natl Acad Sci U S A (2014) 111:18243-18248. DOI 10.1073/pnas.1420914111 · PubMed

Other PDB entries of the same protein (UniProt O14776 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3Q1I 1.4 Å, Polo-like kinase I Polo-box domain in complex with FMPPPMSpSM phosphopeptide from TCERG1
4FQG 2.0 Å, Crystal structure of the TCERG1 FF4-6 tandem repeat domain
3HFH 2.7 Å, Crystal structure of tandem FF domains
8Q7N 3.1 Å, cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region)
9R3D 3.12 Å, Cryo-EM structure of the human pre-Bact-OTS complex (whole map)
7ABF 3.9 Å, Human pre-Bact-1 spliceosome core structure
8QO9 5.29 Å, Cryo-EM structure of a human spliceosomal B complex protomer
7ABG 7.8 Å, Human pre-Bact-1 spliceosome
9R8V 8.5 Å, Cryo-EM structure of the human pre-Bact-OTS complex (whole map)
2DK7 Solution structure of WW domain in transcription elongation regulator 1
2DOD Solution structure of the first FF domain of human transcription factor CA150
2DOE Solution structure of the third FF domain of human transcription factor CA150

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