DNA replication licensing factor MCM7 (MCM7) is a 845-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P38132.
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The mean pLDDT of this model is 77.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 13% |
| 70 to 90 | Confident: backbone generally right | 65% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Acts as a component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to…
Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5; loaded onto DNA, forms a head-head double hexamer. Interacts with CSM1 and MCM10
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7W8G | EM | 2.52 Å | 7/G=1-845 |
| 8RIF | EM | 2.79 Å | 7/F=1-845 |
| 7V3V | EM | 2.9 Å | 7/G=1-845 |
| 7P30 | EM | 3.0 Å | 7/F=1-845 |
| 8KG6 | EM | 3.07 Å | 7=1-845 |
| 7PMK | EM | 3.2 Å | 7=1-845 |
| 7PMN | EM | 3.2 Å | 7=1-845 |
| 7PT6 | EM | 3.2 Å | 7/G=1-845 |
| 7V3U | EM | 3.2 Å | 7/G=1-845 |
| 9E2Y | EM | 3.2 Å | 7=1-845 |
| 7P5Z | EM | 3.3 Å | 7/F=1-845 |
| 7QHS | EM | 3.3 Å | 7=1-845 |
| 9E2W | EM | 3.3 Å | 7=1-845 |
| 9GJW | EM | 3.3 Å | 7=1-845 |
| 6SKO | EM | 3.4 Å | 7=1-845 |
| 9GJP | EM | 3.4 Å | 7=1-845 |
| 8RIG | EM | 3.41 Å | 7=1-845 |
| 8B9A | EM | 3.5 Å | 7=1-845 |
| 8B9B | EM | 3.5 Å | 7=1-845 |
| 9E2X | EM | 3.5 Å | 7=1-845 |
Showing 20 of 55 experimental structures (best resolution first).
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