DNA replication licensing factor MCM6 (MCM6) is a 1017-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P53091.
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The mean pLDDT of this model is 69.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 13% |
| 70 to 90 | Confident: backbone generally right | 50% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 27% |
What pLDDT means and how to read it
Acts as a component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Once loaded onto DNA, double hexamers can slide on dsDNA in the absence of ATPase activity. Required for…
Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5; loaded onto DNA, forms a head-head double hexamer. Interacts with MCM10
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7W8G | EM | 2.52 Å | 6/F=1-1017 |
| 8RIF | EM | 2.79 Å | 6/E=1-1017 |
| 7V3V | EM | 2.9 Å | 6/F=1-1017 |
| 7P30 | EM | 3.0 Å | 6/E=1-1017 |
| 8KG6 | EM | 3.07 Å | 6=1-1017 |
| 7PMK | EM | 3.2 Å | 6=1-1017 |
| 7PMN | EM | 3.2 Å | 6=1-1017 |
| 7PT6 | EM | 3.2 Å | 6/F=1-1017 |
| 7V3U | EM | 3.2 Å | 6/F=1-1017 |
| 9E2Y | EM | 3.2 Å | 6=1-1017 |
| 7P5Z | EM | 3.3 Å | 6/E=1-1017 |
| 7QHS | EM | 3.3 Å | 6=1-1017 |
| 9E2W | EM | 3.3 Å | 6=1-1017 |
| 9GJW | EM | 3.3 Å | 6=1-1017 |
| 6SKO | EM | 3.4 Å | 6=1-1017 |
| 7Z13 | EM | 3.4 Å | 6/e=1-1017 |
| 9GJP | EM | 3.4 Å | 6=1-1017 |
| 8RIG | EM | 3.41 Å | 6=1-1017 |
| 8B9A | EM | 3.5 Å | 6=1-1017 |
| 8B9B | EM | 3.5 Å | 6=1-1017 |
Showing 20 of 55 experimental structures (best resolution first).
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