7ANK: Sarcomeric protein FATZ-1

Crystal structure of sarcomeric protein FATZ-1 (d91-FATZ-1 construct) in complex with half dimer of alpha-actinin-2. Determined by X-ray diffraction at 3.2 Å resolution. Released 30 Jun 2021.

Method
X-ray diffraction
Resolution
3.2 Å
Organism
Homo sapiens
Chains
3
Atoms
7,319
Mol. weight
128.69 kDa
Released
30 Jun 2021

Explore 7ANK in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7ANK contains 41 α-helices and 3 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 22 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix36-5520
α-helix62-654
α-helix70-8011
α-helix85-884
α-helix93-11018
α-helix120-1245
α-helix127-13913
α-helix140-1445
α-helix154-16411
α-helix178-1814
α-helix184-19310
α-helix208-22114
α-helix231-2366
α-helix242-30463
α-helix313-32917
α-helix331-35424
α-helix357-3604
α-helix368-42558
α-helix428-4303
α-helix434-45320
α-helix455-47016
α-helix476-51136
Chain B: 16 helices, 3 β-strands
ElementResiduesLengthSheet
α-helix507-5104
α-helix512-53928
α-helix548-56316
α-helix565-58824
α-helix604-66360
α-helix672-68615
α-helix689-70416
α-helix717-74731
α-helix752-76413
α-helix776-7827
α-helix791-7999
α-helix811-8188
α-helix828-8369
β-strand84511
α-helix847-8537
α-helix856-86510
β-strand86811
β-strand87911
α-helix881-8888
Chain C: 3 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix187-1926
α-helix214-2174
α-helix225-2273

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Alpha-actinin-2Aprotein535Homo sapiensP35609 (AlphaFold model)
Alpha-actinin-2Bprotein389Homo sapiensP35609 (AlphaFold model)
Myozenin-1Cprotein209Homo sapiensQ9NP98 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>7ANK_1 Alpha-actinin-2 (chains A)
MNQIEPGVQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIE
NIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAE
EIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSW
KDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKP
DERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRT
IPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAF
MPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGK
EQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVN
DRCQKICDQWDRLGTLTQKRREALERMSERVRNFEDPAANKARKEAELAAATAEQ
Sequence of entity 2 (B), FASTA
>7ANK_2 Alpha-actinin-2 (chains B)
GSSKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATL
PEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSL
QEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNI
INYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQILTR
DAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDLGEAEFARIMTLVDPNG
QGTVTFQSFIDFMTRETADTDTAEQVIASFRILASDKPYILAEELRRELPPDQAQYCIKR
MPAYSGPGSVPGALDYAAFSSALYGESDL
Sequence of entity 3 (C), FASTA
>7ANK_3 Myozenin-1 (chains C)
GPTVGGQLGTAGQGFSYSKSNGRGGSQAGGSGSAGQYGSDQQHHLGSGSGAGGTGGPAGQ
AGRGGAAGTAGVGETGSGDQAGGEGKHITVFKTYISPWERAMGVDPQQKMELGIDLLAYG
AKAELPKYKSFNRTAMPYGGYEKASKRMTFQMPKFDLGPLLSEPLVLYNQNLSNRPSFNR
TPIPWLSSGEPVDYNVDIGIPLDGETEEL

Primary citation

Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with alpha-actinin. Sponga, A., Arolas, J.L., Schwarz, T.C. et al. Sci Adv (2021) 7. DOI 10.1126/sciadv.abg7653 · PubMed

Other PDB entries of the same protein (UniProt P35609 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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