Alpha-actinin-2 (ACTN2) is a 894-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P35609.
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The mean pLDDT of this model is 84.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 47% |
| 70 to 90 | Confident: backbone generally right | 42% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein
Homodimer; antiparallel. Also forms heterodimers with ACTN3. Interacts with ADAM12, MYOZ1, MYOZ2 and MYOZ3. Interacts via its C-terminal region with the LDB3 PDZ domain. Interacts with XIRP2. Interacts with DST isoform 1 (via N-terminus). Interacts with PARVB. Interacts with SYNPO2
Cytoplasm, myofibril, sarcomere, Z line
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6SWT | X-ray | 1.2 Å | A=19-270 |
| 6TS3 | X-ray | 1.28 Å | A/B=825-894 |
| 7B56 | X-ray | 1.45 Å | A=825-894 |
| 7B55 | X-ray | 1.6 Å | A=825-894 |
| 5A37 | X-ray | 1.88 Å | A/B=19-266 |
| 5A38 | X-ray | 1.9 Å | A/B=19-266 |
| 7B57 | X-ray | 1.95 Å | A=825-894 |
| 5A36 | X-ray | 2.0 Å | A/B=19-266 |
| 5A4B | X-ray | 2.01 Å | A/B=19-266 |
| 1QUU | X-ray | 2.5 Å | A=391-637 |
| 7A8T | X-ray | 2.69 Å | A=274-746 |
| 1HCI | X-ray | 2.8 Å | A/B=274-746 |
| 7ANK | X-ray | 3.2 Å | A=1-507, B=509-894 |
| 4D1E | X-ray | 3.5 Å | A=19-894 |
| 7A8U | X-ray | 3.8 Å | A=274-746 |
| 1H8B | NMR | A=822-894 |
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