Extracellular calcium-sensing receptor (CASR) is a 1078-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P41180.
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The mean pLDDT of this model is 75.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 43% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
G protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:22789683, PubMed:23966241, PubMed:25104082, PubMed:25292184, PubMed:25766501, PubMed:26386835, PubMed:32817431, PubMed:33603117, PubMed:34194040, PubMed:34467854, PubMed:7759551, PubMed:8636323, PubMed:8702647, PubMed:8878438). Senses fluctuations in the circulating calcium concentration: activated by elevated circulating calcium, leading to decreased parathyroid hormone (PTH) secretion in parathyroid glands (By similarity). In kidneys, acts as a key regulator of…
Homodimer; disulfide-linked (PubMed:10077597, PubMed:16740594, PubMed:27386547, PubMed:27434672, PubMed:32817431, PubMed:34194040, PubMed:34467854, PubMed:37919470). Interacts with VCP (PubMed:16513638). Interacts with ARRB1 (By similarity)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5FBK | X-ray | 2.1 Å | A/B=20-541 |
| 7M3G | EM | 2.5 Å | A/B=20-894 |
| 5K5S | X-ray | 2.6 Å | A/B=20-607 |
| 5FBH | X-ray | 2.7 Å | A/B=20-541 |
| 7SIL | EM | 2.7 Å | A/B=1-870 |
| 7SIM | EM | 2.7 Å | A/B=1-870 |
| 8WPG | EM | 2.7 Å | A/B=20-892 |
| 7M3F | EM | 2.8 Å | A/B=20-894 |
| 8SZF | EM | 2.8 Å | A/B=19-894 |
| 9C1P | EM | 2.8 Å | A/B=19-894 |
| 9C2F | EM | 2.8 Å | A/B=19-894 |
| 7E6T | EM | 3.0 Å | A/B=20-870 |
| 5K5T | X-ray | 3.1 Å | A=20-607 |
| 8SZH | EM | 3.1 Å | A/B=19-894 |
| 8WPU | EM | 3.1 Å | A/B=20-907 |
| 7M3E | EM | 3.2 Å | A/B=20-894 |
| 9ASB | EM | 3.4 Å | Q/R=1-903 |
| 7DTV | EM | 3.5 Å | A/B=20-1078 |
| 8SZI | EM | 3.5 Å | A/B=19-894 |
| 9AXF | EM | 3.5 Å | Q/R=1-903 |
Showing 20 of 31 experimental structures (best resolution first).
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