GPCRs and cell signaling

G protein-coupled receptors (GPCRs) are the largest family of membrane receptors and the targets of about a third of approved drugs. They detect light, smells, hormones and neurotransmitters, then switch on G proteins inside the cell. The beta-2 adrenergic receptor structures were recognized by the 2012 Nobel Prize in Chemistry.

Open Bovine rhodopsin in 3D

28 structures

Bovine rhodopsin1F88
The first GPCR structure, solved in 2000.
Human beta-2 adrenergic receptor2RH1
Beta-2 adrenergic receptor bound to Gs protein3SN6
Adenosine A2A receptor with antagonist ZM2413853EML
Adenosine A2A receptor at 1.8 Å4EIY
Mouse mu-opioid receptor with an antagonist4DKL
Active mouse mu-opioid receptor with agonist BU725C1M
Mouse mu-opioid receptor bound to Gi protein6DDE
Kappa-opioid receptor4DJH
Dopamine D3 receptor with eticlopride3PBL
Dopamine D2 receptor with risperidone6CM4
M2 muscarinic acetylcholine receptor3UON
Active M2 muscarinic receptor with iperoxo4MQS
Cannabinoid receptor CB15TGZ
Serotonin 5-HT2A receptor with risperidone6A93
Serotonin 5-HT2A receptor with LSD6WGT
Serotonin 5-HT2B receptor with ergotamine4IB4
CXCR4 chemokine receptor3ODU
CCR5 chemokine receptor with maraviroc4MBS
CCR5 is a co-receptor HIV uses to enter cells.
Angiotensin II type 1 receptor with olmesartan4ZUD
Protease-activated receptor 1 with vorapaxar3VW7
Metabotropic glutamate receptor 14OR2
Smoothened receptor with an anticancer drug4JKV
Orexin 2 receptor with suvorexant4S0V
GLP-1 receptor bound to Gs protein5VAI
GABA-B receptor in the active state7C7Q
Human beta-2 adrenergic receptor (AlphaFold)P07550 (AlphaFold)
Human mu-opioid receptor (AlphaFold)P35372 (AlphaFold)

More collections