13GJ: IST1

IST1 bound to PI(4,5)P2 containing membrane. Determined by electron microscopy at 2.0 Å resolution. Released 8 Jul 2026.

Method: Electron microscopy
Resolution: 2.0 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,583
Mol. weight: 40.54 kDa
Ligands: PIO
Released: 8 Jul 2026

Explore 13GJ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

13GJ contains 11 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 0 β-strands

Element	Residues	Length
α-helix	8-45	38
α-helix	49-81	33
α-helix	83-88	6
α-helix	92-93	2
α-helix	94-110	17
α-helix	115-128	14
α-helix	130-137	8
α-helix	146-151	6
α-helix	156-158	3
α-helix	159-173	15
α-helix	181-184	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
IST1 homolog	A	protein	364	Homo sapiens	P53990 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>13GJ_1 IST1 homolog (chains A)
MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHII
REDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIV
ADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPD
SVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPSAN
TPFSYPLPKGPSDFNGLPMGTYQAFPNIHPPQIPATPPSYESVDDINADKNISSAQIVGP
GPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFEEL
KKKT

Ligands and cofactors

ID	Name	Formula	Copies
PIO	[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-d…	C25 H49 O19 P3	1

Primary citation

Phosphatidylinositol diphosphate binding by ESCRT-III filaments. Alian, A., McCullough, J., Moss 3rd, F.R. et al. Proc Natl Acad Sci U S A (2026) 123:e2616668123-e2616668123. DOI 10.1073/pnas.2616668123 · PubMed

Other PDB entries of the same protein (UniProt P53990 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7S7J 1.15 Å, Structure of Human SPASTIN-IST1 complex.
4WZX 1.39 Å, ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins
4U7E 1.6 Å, The crystal structure of the complex of LIP5 NTD and IST1 MIM
4U7I 1.79 Å, Structure of the complex of Spartin MIT and IST1 MIM
3FRR 1.8 Å, Structure of human IST1(NTD) - (residues 1-189)(P21)
4U7Y 2.5 Å, Structure of the complex of VPS4B MIT and IST1 MIM
13GH 2.56 Å, IST1 bound to PI(3,5)P2 containing membrane
3FRS 2.61 Å, Structure of human IST1(NTD) (residues 1-189)(p43212)
8UC6 2.7 Å, Calpain-7:IST1 Complex
8V2S 2.72 Å, CHMP1B/IST1 dsDNA bound copolymer
6E8G 2.9 Å, CryoEM reconstruction of IST1-CHMP1B copolymer filament bound to ssDNA at 2.9 Angstrom…
8V2Q 2.95 Å, CHMP1B/IST1 ssRNA bound copolymer

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