IST1 homolog (IST1) is a 364-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P53990.
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The mean pLDDT of this model is 72.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 47% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 33% |
What pLDDT means and how to read it
ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (PubMed:19129479, PubMed:26040712, PubMed:28242692). Is required for efficient abscission during cytokinesis (PubMed:19129479). Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (PubMed:28242692). Regulates…
Interacts with CHMP1A, CHMP1B, VPS4A and VTA1. Interacts with SPAST, STAMBP, and USP8. May interact with VPS37B. May associate with the ESCRT-I complex. Interacts with MITD1, in competition with VSP4 (PubMed:23015756). Interacts with SPART (via MIT domain); leading to the recruitment of SPART to midbodies (PubMed:20719964). Interacts with SPAST (PubMed:23897888, PubMed:26040712)
Cytoplasmic vesicle, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Midbody, Nucleus envelope
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7S7J | X-ray | 1.15 Å | B=342-364 |
| 4WZX | X-ray | 1.39 Å | E=342-364 |
| 4U7E | X-ray | 1.6 Å | A=341-364 |
| 4U7I | X-ray | 1.79 Å | B=341-364 |
| 3FRR | X-ray | 1.8 Å | A=1-189 |
| 4U7Y | X-ray | 2.5 Å | B=341-364 |
| 3FRS | X-ray | 2.61 Å | A=5-189 |
| 8UC6 | X-ray | 2.7 Å | E/G=320-364 |
| 8V2S | EM | 2.72 Å | B=1-364 |
| 6E8G | EM | 2.9 Å | A/BA/BB/C/DA/DB/E/FA/FB/G/HA/HB/I/JA/JB/K/LA/LB/M/NA/NB/O/PA/PB/Q/RA/RB/S/TA/TB=1-364 |
| 8V2Q | EM | 2.95 Å | B=1-364 |
| 8V2R | EM | 3.01 Å | B=1-364 |
| 6TZ5 | EM | 3.1 Å | A/BA/BB/C/DA/DB/E/FA/FB/G/HA/HB/I/JA/JB/K/LA/LB/M/NA/NB/O/PA/PB/Q/RA/S/TA/V/VA=1-189 |
| 6TZ4 | EM | 3.2 Å | 01/AA/AB/B/CA/CB/D/EA/EB/F/GA/GB/H/IA/IB/J/KA/KB/L/MA/MB/N/OA/OB/P/QA/QB/R/SA/SB=1-189 |
| 3JC1 | EM | 4.0 Å | Aa/Ac/Ae/Ag/Ai/Ak/Am/Ao/Aq/As/Au/Aw/Ay/Ba/Bc/Be/Bg/Bi/Bk/Bm/Bo/Bq/Bs/Bu/Bw/By/Ca/Cc/Ce/Cg=6-187 |
| 6TZA | EM | 7.2 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N=1-189 |
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