5MK5: DHBN domain of human BLM helicase

Structures of DHBN domain of human BLM helicase. Determined by X-ray diffraction at 2.16 Å resolution. Released 1 Mar 2017.

Method: X-ray diffraction
Resolution: 2.16 Å
Organism: Homo sapiens
Chains: 4
Atoms: 1,830
Mol. weight: 28.22 kDa
Released: 1 Mar 2017

Explore 5MK5 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5MK5 contains 12 α-helices and 0 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	365-384	20
α-helix	388-391	4
α-helix	397-411	15

Chain B: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	363-384	22
α-helix	388-391	4
α-helix	397-411	15

Chain C: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	363-383	21
α-helix	388-391	4
α-helix	397-411	15

Chain D: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	366-385	20
α-helix	388-391	4
α-helix	397-410	14

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Bloom syndrome protein	A, B, C, D	protein	54	Homo sapiens	P54132 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>5MK5_1 Bloom syndrome protein (chains A, B, C, D)
MDARQISLQQQLIHVMEHICKLIDTIPDDKLKLLDCGNELLQQRNIRRKLLTEV

Primary citation

A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation. Shi, J., Chen, W.F., Zhang, B. et al. J Biol Chem (2017) 292:5909-5920. DOI 10.1074/jbc.M116.761510 · PubMed

Other PDB entries of the same protein (UniProt P54132 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7XV0 1.5 Å, Crystal structure of RPA70N-BLMp1 fusion
7AUC 1.53 Å, Crystal structure of an engineered helicase domain construct for human Bloom syndrome…
7XUW 1.8 Å, Crystal structure of RPA70N-BLMp2 fusion
9P3E 2.0 Å, LC3B bound to BLM peptide
5LUP 2.03 Å, Structures of DHBN domain of human BLM helicase
4O3M 2.3 Å, Ternary complex of Bloom's syndrome helicase
5U6K 2.6 Å, Crystal structure of TopBP1 BRCT4/5 in complex with a BLM phosphopeptide
3WE2 2.7 Å, Structure of BLM RQC domain bound to a phosphate ion
4CDG 2.79 Å, Crystal structure of the Bloom's syndrome helicase BLM in complex with Nanobody
3WE3 2.9 Å, Structure of BLM RQC domain bound to an arsenate ion
7AUD 2.96 Å, Structure of an engineered helicase domain construct for human Bloom syndrome protein…
4CGZ 3.2 Å, Crystal structure of the Bloom's syndrome helicase BLM in complex with DNA

Browse structure collections

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