RecQ-like DNA helicase BLM (BLM) is a 1417-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P54132.
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The mean pLDDT of this model is 60.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 30% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 51% |
What pLDDT means and how to read it
ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA;…
Monomer (PubMed:28228481). Homodimer (via N-terminus) (PubMed:28228481). Homotetramer (via N-terminus); dimer of dimers (PubMed:28228481). Homohexamer (via N-terminus) (PubMed:28228481). Self-association negatively regulates DNA unwinding amplitude and rate. Oligomeric complexes dissociate into monomer in presence of ATP (PubMed:28228481). Part of the BRCA1-associated genome surveillance complex…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7XV0 | X-ray | 1.5 Å | B=146-165 |
| 7AUC | X-ray | 1.53 Å | A=636-1070, A=1202-1298 |
| 7XUW | X-ray | 1.8 Å | A=550-570 |
| 5LUP | X-ray | 2.03 Å | A/B/C/D/E/F/G/H/I/J/K/L=362-414 |
| 5MK5 | X-ray | 2.16 Å | A/B/C/D=362-414 |
| 4O3M | X-ray | 2.3 Å | A=640-1298 |
| 5U6K | X-ray | 2.6 Å | L/M/N/O=297-309 |
| 3WE2 | X-ray | 2.7 Å | A/B=1068-1209 |
| 4CDG | X-ray | 2.79 Å | A/B=636-1298 |
| 3WE3 | X-ray | 2.9 Å | A/B=1068-1209 |
| 7AUD | X-ray | 2.96 Å | A/B/C/D/E/F=636-1070, A/B/C/D/E/F=1202-1298 |
| 4CGZ | X-ray | 3.2 Å | A=636-1298 |
| 2KV2 | NMR | A=1210-1294 | |
| 2MH9 | NMR | A=1067-1210 | |
| 2RRD | NMR | A=1200-1295 |
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